Lower Urinary Tract and Gastrointestinal Dysfunction Are Common in Early Parkinson’s Disease
المؤلفون المشاركون
Martinez-Ramirez, Daniel
Velazquez-Avila, Edna Sophia
Almaraz-Espinoza, Alejandro
Gonzalez-Cantú, Arnulfo
Vazquez-Elizondo, Genaro
Overa-Posada, Daniel
Cervantes-Arriaga, Amin
Rodriguez-Violante, Mayela
Gonzalez-Gonzalez, Mirna
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
Autonomic dysfunction is a common nonmotor feature and early manifestation of Parkinsons disease (PD).
Autonomic dysfunction in PD is associated with a worse prognosis.
We sought to characterize autonomic dysfunction and identify associated factors in patients with early PD.
Methods.
An observational, cross-sectional, descriptive, and analytical study was conducted to evaluate patients with early PD from the Parkinsons Progression Markers Initiative.
We utilized the Scales for Outcomes in Parkinsons Disease-Autonomic dysfunction questionnaire to determine the prevalence and frequencies of autonomic symptomatology.
The cohort was grouped into high and low dysautonomic scores.
A regression model identified variables that independently explained dysautonomic scores in our early PD cohort.
Results.
414 PD patients had a mean age of 61.1 (SD 9.7) years at diagnosis and mean disease duration of 6.7 (SD 6.6) months.
Among all patients, 43.7% (181/414) had high dysautonomic scores.
Urinary and gastrointestinal symptoms were the most prevalent and frequently reported dysautonomic symptoms.
Patients with fatigue (beta = 4.28, p<0.001), probable rapid eye movement sleep behavior disorder (beta = 2.71, p<0.001), excessive daytime sleepiness (beta = 1.88,p=0.039), impulsivity and compulsivity (beta = 2.42, p<0.001), and increasing age (beta = 1.05, p<0.001) were more likely to have high dysautonomic scores.
Conclusion.
Lower urinary tract and gastrointestinal symptoms are prevalent and frequent in early PD patients.
Fatigue, sleep disorders, impulsivity and compulsivity, and age are predictors of autonomic dysfunction.
Autonomic symptoms predominated in this group of early PD patients in the disease course and were associated with more severe disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Martinez-Ramirez, Daniel& Velazquez-Avila, Edna Sophia& Almaraz-Espinoza, Alejandro& Gonzalez-Cantú, Arnulfo& Vazquez-Elizondo, Genaro& Overa-Posada, Daniel…[et al.]. 2020. Lower Urinary Tract and Gastrointestinal Dysfunction Are Common in Early Parkinson’s Disease. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1206398
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Martinez-Ramirez, Daniel…[et al.]. Lower Urinary Tract and Gastrointestinal Dysfunction Are Common in Early Parkinson’s Disease. Parkinson’s Disease No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1206398
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Martinez-Ramirez, Daniel& Velazquez-Avila, Edna Sophia& Almaraz-Espinoza, Alejandro& Gonzalez-Cantú, Arnulfo& Vazquez-Elizondo, Genaro& Overa-Posada, Daniel…[et al.]. Lower Urinary Tract and Gastrointestinal Dysfunction Are Common in Early Parkinson’s Disease. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1206398
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206398
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر