Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients
المؤلفون المشاركون
Katulanda, P.
Gunawardena, Harshi Prasadini
Silva, Renuka
Sivakanesan, Ramiah
Ranasinghe, Pathmasiri
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Glycaemic control is the main focus of managing diabetes and its complications.
Hyperglycaemia induces oxidative stress favouring cellular damage and subsequent diabetic complications.
The present study was conducted to compare the plasma total antioxidant capacity (TAC) and individual antioxidant marker antioxidant status of type 2 diabetics (T2D) with good ((+) GC) and poor ((-) GC) glycaemic control with prediabetic (PDM) and normoglycaemic (NG) individuals.
T2D (n=147), PDM (n=47), and NGC (n=106) were recruited as subjects.
T2D and PDM had lower plasma TAG than NG subjects.
T2D and PDM had significantly higher GPx activity and plasma MDA concentrations than NG.
PDM showed the highest SOD activity.
T2D (-) GC showed significantly elevated GPx activity and higher MDA level and significantly lower SOD activity among all study groups.
Lower plasma TAC and higher plasma MDA indicate the presence of oxidative stress in T2D and PDM.
Elevated GPx activity in T2D, PDM, and particularly in T2D (-) GC suggests a compensatory response to counteract excess lipid peroxidation in the hyperglycaemic state.
Decline in SOD activity advocates the presence of glycation and excess lipid peroxidation in T2D.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gunawardena, Harshi Prasadini& Silva, Renuka& Sivakanesan, Ramiah& Ranasinghe, Pathmasiri& Katulanda, P.. 2019. Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1206414
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gunawardena, Harshi Prasadini…[et al.]. Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1206414
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gunawardena, Harshi Prasadini& Silva, Renuka& Sivakanesan, Ramiah& Ranasinghe, Pathmasiri& Katulanda, P.. Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1206414
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206414
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر