Effect of Intestinal Levodopa-Carbidopa Infusion on Pharyngeal Dysphagia: Results from a Retrospective Pilot Study in Patients with Parkinson’s Disease
المؤلفون المشاركون
Labeit, Bendix
Claus, Inga
Muhle, Paul
Suntrup-Krueger, Sonja
Dziewas, Rainer
Warnecke, Tobias
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Pharyngeal dysphagia is a common symptom of Parkinson’s disease (PD) leading to severe complications.
PD-related pharyngeal dysphagia (PDrPD) may significantly improve in up to half of patients following acute oral levodopa challenge.
Objective.
The aim of this study was to investigate the effects of levodopa-carbidopa intestinal gel (LCIG) on PDrPD.
Methods.
Forty-five PD patients under LCIG treatment were available for retrospective analysis.
In all patients with PDrPD who underwent flexible endoscopic evaluation of swallowing (FEES) in the clinical “on-state” both before and after implementation of LCIG treatment, FEES videos were systematically reassessed.
PDrPD was characterized using a PD-specific FEES score evaluating premature bolus spillage, penetration/aspiration, and pharyngeal residue.
Further, the duration of white-out was assessed, as a parameter for pharyngeal bradykinesia.
Results.
Eleven patients with PDrPD (mean age 74.6 ± 4.4 years; mean Hoehn and Yahr stage 3.8 ± 0.6) received FEES both before and after the onset of LCIG treatment.
The mean swallowing score improved from 14.9 ± 7.3 to 13.0 ± 6.9 after implementation of LCIG; however, this difference was not significant (p=0.312).
Premature bolus spillage decreased significantly (p=0.002) from 5.4 ± 1.1 to 3.6 ± 1.0, and white-out duration decreased significantly (p=0.002) from 984 ± 228 ms to 699 ± 131 ms after implementation of LCIG.
Conclusions.
LCIG may affect PDrPD and reduce premature bolus spillage and pharyngeal bradykinesia.
Future studies with larger sample sizes are required to follow-up on these pilot results and identify which factors predict a good response of PDrPD to LCIG treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Labeit, Bendix& Claus, Inga& Muhle, Paul& Suntrup-Krueger, Sonja& Dziewas, Rainer& Warnecke, Tobias. 2020. Effect of Intestinal Levodopa-Carbidopa Infusion on Pharyngeal Dysphagia: Results from a Retrospective Pilot Study in Patients with Parkinson’s Disease. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1206450
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Labeit, Bendix…[et al.]. Effect of Intestinal Levodopa-Carbidopa Infusion on Pharyngeal Dysphagia: Results from a Retrospective Pilot Study in Patients with Parkinson’s Disease. Parkinson’s Disease No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1206450
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Labeit, Bendix& Claus, Inga& Muhle, Paul& Suntrup-Krueger, Sonja& Dziewas, Rainer& Warnecke, Tobias. Effect of Intestinal Levodopa-Carbidopa Infusion on Pharyngeal Dysphagia: Results from a Retrospective Pilot Study in Patients with Parkinson’s Disease. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1206450
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206450
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر