Evolution of Initial Pharmacologic Treatment of Newly Diagnosed Parkinson’s Disease Patients over a Decade in Singapore
المؤلفون المشاركون
Li, Wei
Neo, Shermyn X. M.
Tay, Kay-Yaw
Au, Wing-Lok
Tan, Louis C. S.
Wong, Sheng Yong Aidan
Ng, Hwee Lan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
The aim of this study is to compare Parkinson’s disease (PD) treatment practices by movement disorder (MD) specialists across a decade, and to determine the factors that influence drug choice for the motor symptoms of PD in newly diagnosed drug-naïve patients.
Methods.
This prospective temporal analysis included patients seen at the National Neuroscience Institute in Singapore and diagnosed with PD by MD specialists in the years 2007 and 2017.
Primary outcomes were use of specific PD drugs and changes in drug-prescribing patterns.
Descriptive analyses and multivariable logistic regression models determined the extent to which patient characteristics were associated with type of PD treatment.
Results.
Of 230 patients with PD (mean (SD) age, 66.7 (10.3) years), 131 (57.0%) were male.
From 2007 to 2017, the use of ergot dopamine agonists and anticholinergics decreased from 19.3% to 2.0% (P<0.001) and from 12.0% to 2.7% (P=0.004), respectively.
The use of monoamine oxidase B inhibitors (MAOBI) increased from 13.3% to 25.2% (P=0.033).
The use of levodopa (LD)-sparing strategies decreased nonsignificantly from 33.7% to 24.5% (P=0.133).
Overall, 196 (85.2%) patients were initiated on symptomatic monotherapy, with LD being the most commonly prescribed.
MAOBI was the most common drug used in combination therapy.
Age ≤70 (adjusted OR, 11.9; 95% CI, 4.5–31.5) and Hoehn and Yahr (HY) stage <2 (adjusted OR, 3.4; 95% CI, 1.5–7.7) were independent factors for LD-sparing strategies.
Non-LD prescriptions (13 of 92; 14.1%) were more likely to be discontinued compared to LD ones (6 of 149; 4.0%) (P=0.005).
Conclusions.
Drug-prescribing patterns in PD have changed significantly through the last decade, influenced by emerging evidence and reports of adverse drug effects.
Choosing drugs based on the patient’s age and disease severity remain sound guiding principles across the years.
It is important that international and national guidelines for pharmacotherapy in PD be updated consistently throughout different socioeconomic settings to optimize care.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Neo, Shermyn X. M.& Wong, Sheng Yong Aidan& Ng, Hwee Lan& Li, Wei& Tay, Kay-Yaw& Au, Wing-Lok…[et al.]. 2020. Evolution of Initial Pharmacologic Treatment of Newly Diagnosed Parkinson’s Disease Patients over a Decade in Singapore. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1206477
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Neo, Shermyn X. M.…[et al.]. Evolution of Initial Pharmacologic Treatment of Newly Diagnosed Parkinson’s Disease Patients over a Decade in Singapore. Parkinson’s Disease No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1206477
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Neo, Shermyn X. M.& Wong, Sheng Yong Aidan& Ng, Hwee Lan& Li, Wei& Tay, Kay-Yaw& Au, Wing-Lok…[et al.]. Evolution of Initial Pharmacologic Treatment of Newly Diagnosed Parkinson’s Disease Patients over a Decade in Singapore. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1206477
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206477
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر