Isoflurane Preconditioning Attenuates Brain Injury Induced by Electromagnetic Pulse via the TLR4NFκB Signaling Pathway

المؤلفون المشاركون

Zhang, Xiajing
Li, Jiang-Jing
Deng, Bin
Lv, Miao-Miao
Zhao, Hui
Wang, Jin
Liu, Ji-Dong
Han, Rui-Li
Sun, Xu-De

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-01-06

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الأحياء

الملخص EN

Electromagnetic pulse (EMP) is a unique type of electromagnetic radiation, and EMP exposure causes a series of biological effects.

The nervous system is sensitive to EMP.

We studied the neuroprotective effects of isoflurane preconditioning against EMP exposure and used hematoxylin-eosin staining (HE) to observe the effects of electromagnetic pulse and isoflurane preconditioning on neurons.

Inflammatory cytokines were detected by enzyme-linked immunosorbent assay (ELISA).

Western blotting was used to detect the expression of caspase-3, CD11b, TLR4, and NFκBp65.

We found that after EMP exposure, the number of abnormal neurons had increased, and the expression of caspase-3, CD11b, TLR4, and NFκBp65 had also increased.

Isoflurane preconditioning can reverse the above phenomenon.

Moreover, we found that isoflurane preconditioning can reduce neuronal apoptosis and improve cognitive impairment induced by EMP.

These findings indicate that isoflurane preconditioning can protect neurons in the cerebral cortex from EMP exposure, alleviate the inflammatory reaction and cell apoptosis, and improve cognitive impairment induced by EMP.

These effects may occur through the downregulation of the TLR4/NFκB signaling pathway and the inhibition of microglial activation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Jiang-Jing& Deng, Bin& Zhang, Xiajing& Lv, Miao-Miao& Zhao, Hui& Wang, Jin…[et al.]. 2019. Isoflurane Preconditioning Attenuates Brain Injury Induced by Electromagnetic Pulse via the TLR4NFκB Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1206505

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Jiang-Jing…[et al.]. Isoflurane Preconditioning Attenuates Brain Injury Induced by Electromagnetic Pulse via the TLR4NFκB Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1206505

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Jiang-Jing& Deng, Bin& Zhang, Xiajing& Lv, Miao-Miao& Zhao, Hui& Wang, Jin…[et al.]. Isoflurane Preconditioning Attenuates Brain Injury Induced by Electromagnetic Pulse via the TLR4NFκB Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1206505

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1206505