Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease
المؤلفون المشاركون
Anderton, R. S.
Bakeberg, Megan C.
Riley, Maddeson
Byrnes, Michelle
Jefferson, Alexa
Ghosh, Souyma
Horne, Malcom K.
McGregor, Sarah
Stell, Rick
Walters, Sue
Evans, Tess
Roberts, Katherine
Mastaglia, Frank L.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Heightened impulsivity has been reported in a subset of people with Parkinson’s disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs).
However, at present, there are no recognised biochemical markers of heightened impulsivity.
Objectives.
To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP.
Methods.
The study measured serum ceruloplasmin and impulsivity using the Barratt Impulsiveness Scale (BIS-11) in an Australian cohort of 214 PwP.
Multivariate general linear models (GLMs) were used to identify whether higher serum ceruloplasmin levels (>75th percentile) were significantly predictive of BIS-11 scores.
Results.
Serum ceruloplasmin was higher in females with PD (p<0.001) and associated with MDS-UPDRS III, Hoehn and Yahr, and ACE-R scores (p<0.05).
When correcting for covariates, higher serum ceruloplasmin concentrations were associated with the 2nd order nonplanning impulsivity and with the 1st order self-control and cognitive complexity impulsivity domains.
Conclusions.
Higher serum ceruloplasmin levels are independently associated with heightened nonplanning impulsivity in PwP.
Thus, serum ceruloplasmin levels may have clinical utility as a marker for heightened impulsivity in PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bakeberg, Megan C.& Riley, Maddeson& Byrnes, Michelle& Jefferson, Alexa& Ghosh, Souyma& Horne, Malcom K.…[et al.]. 2020. Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1206506
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bakeberg, Megan C.…[et al.]. Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease. Parkinson’s Disease No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1206506
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bakeberg, Megan C.& Riley, Maddeson& Byrnes, Michelle& Jefferson, Alexa& Ghosh, Souyma& Horne, Malcom K.…[et al.]. Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1206506
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206506
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر