Cerebroprotective Effect against Cerebral Ischemia of the Combined Extract of Oryza sativa and Anethum graveolens in Metabolic Syndrome Rats
المؤلفون المشاركون
Wattanathorn, Jintanaporn
Ohnon, Warin
Tong-Un, Terdthai
Wannanon, Panakaporn
Muchimapura, Supaporn
Thukham-mee, Wipawee
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-11
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
The novel strategy against ischemic stroke in metabolic syndrome (MetS) targeting at oxidative stress and inflammation has gained attention due to the limitation of the current therapy.
Due to the antioxidant and anti-inflammation of the combined extract of Oryza sativa and Anethum graveolens, the cerebroprotective effect against cerebral ischemia in MetS condition has been focused.
Since no data were available, this study was set up to determine the effects of the combined extract of Oryza sativa L.
and Anethum graveolens Linn.
against ischemic stroke in the animal model of metabolic syndrome.
The possible underlying mechanism was also further investigated.
Male Wistar rats (180-220 g) were fed with high-carbohydrate high-fat diet (HCHF diet) to induce metabolic syndrome-like condition.
Then, MetS rats were subjected to reperfusion injury at the right middle cerebral artery.
The combined extract of O.
sativa and A.
graveolens (OA extract) at doses of 0.5, 5, and 50 mg/kg BW was fed once daily for 21 days.
Neurological assessment was performed every 7 days throughout the experimental period.
At the end of study, brain infarction volume, neuron and glial fibrillary acidic protein- (GFAP-) positive cell density, the oxidative stress status, the expressions of proinflammatory cytokines (NF-κB, IL-6), and eNOS in the cortical area together with the expression of VCAM-1 and the histological changes of common carotid artery were determined.
It was found that OA extract decreased brain infarction, neurological score, oxidative stress status, and inflammatory mediators but increased eNOS expression in the cortical area; the increased VCAM-1 and intima-media thickness together with the reduction of lumen diameter of common carotid artery of MetS eats with MCAO were also mitigated by OA extract.
These data suggest the cerebroprotective effect of OA, and the underlying mechanism may occur partly via the improvement of oxidative stress status, inflammation, and brain blood supply.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wattanathorn, Jintanaporn& Ohnon, Warin& Thukham-mee, Wipawee& Muchimapura, Supaporn& Wannanon, Panakaporn& Tong-Un, Terdthai. 2019. Cerebroprotective Effect against Cerebral Ischemia of the Combined Extract of Oryza sativa and Anethum graveolens in Metabolic Syndrome Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1206516
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wattanathorn, Jintanaporn…[et al.]. Cerebroprotective Effect against Cerebral Ischemia of the Combined Extract of Oryza sativa and Anethum graveolens in Metabolic Syndrome Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1206516
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wattanathorn, Jintanaporn& Ohnon, Warin& Thukham-mee, Wipawee& Muchimapura, Supaporn& Wannanon, Panakaporn& Tong-Un, Terdthai. Cerebroprotective Effect against Cerebral Ischemia of the Combined Extract of Oryza sativa and Anethum graveolens in Metabolic Syndrome Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1206516
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206516
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر