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Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria
المؤلفون المشاركون
Hireche, Ahmed
Mimouni, Asma
Rouleau, Etienne
Saulnier, Patrick
Marouani, Amina
Abdelali, Med Lamine
Filali, Taha
Beddar, Leila
Lakehal, Abdelhak
Boudersa, Asma
Aissaoui, Mahmoud
Ramtani, Hacene
Bouhedjar, Khalid
Abdellouche, Djamel
Oudjehih, Messaouda
Boudokhane, Ibtissem
Abadi, Noureddine
Satta, Dalila
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Lung cancer remains the most common cancer in the world.
The genetic polymorphisms (rs2853669 in TERT, rs1052133 in OGG1, and rs16969968 in CHRNA5 genes) were shown to be strongly associated with the risk of lung cancer.
Our study’s aim is to elucidate whether these polymorphisms predispose Eastern Algerian population to non-small-cell lung cancer (NSCLC).
To date, no study has considered this association in the Algerian population.
This study included 211 healthy individuals and 144 NSCLC cases.
Genotyping was performed using TaqMan probes and Sanger sequencing, and the data were analyzed using multivariate logistic regression adjusted for covariates.
The minor allele frequencies (MAFs) of TERT rs2853669, CHRNA5 rs16969968, and OGG1 rs1052133 polymorphisms in controls were C: 20%, A: 31%, and G: 29%, respectively.
Of the three polymorphisms, none shows a significant association, but stratified analysis rs16969968 showed that persons carrying the AA genotype are significantly associated with adenocarcinoma risk (pAdj=0.03, ORAdj=2.55).
Smokers with an AA allele have a larger risk of lung cancer than smokers with GG or GA genotype (pAdj=0.03, ORAdj=3.91), which is not the case of nonsmokers.
Our study suggests that CHRNA5 rs16969968 polymorphism is associated with a significant increase of lung adenocarcinoma risk and with a nicotinic addiction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mimouni, Asma& Rouleau, Etienne& Saulnier, Patrick& Marouani, Amina& Abdelali, Med Lamine& Filali, Taha…[et al.]. 2020. Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria. Pulmonary Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1206576
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mimouni, Asma…[et al.]. Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria. Pulmonary Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1206576
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mimouni, Asma& Rouleau, Etienne& Saulnier, Patrick& Marouani, Amina& Abdelali, Med Lamine& Filali, Taha…[et al.]. Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria. Pulmonary Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1206576
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206576
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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