Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential
المؤلفون المشاركون
Bouvier, Damien
Demaison, Luc
Leger, Thibault
Traoré, Amidou
Cassagnes, Lucie
Rigaudière, Jean-Paul
Jouve, Chrystèle
Pagès, Guilhem
Bonny, Jean-Marie
Sapin, Vincent
Pereira, Bruno
Azarnoush, K.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-26
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Sepsis still causes death, often through cardiac failure and mitochondrial dysfunction.
Dietary ω3 polyunsaturated fatty acids are known to protect against cardiac dysfunction and sepsis lethality.
This study set out to determine whether early low-severity sepsis alters the cardiac mitochondrial function in animals fed a Western-type diet and whether dietary eicosapentaenoic acid (EPA) administration protects the myocardium against the deleterious effects of sepsis and if so to seek possible mechanisms for its effects.
Rats were divided into two groups fed either an ω3 PUFA-deficient diet (“Western diet,” DEF group) or an EPA-enriched diet (EPA group) for 5 weeks.
Each group was subdivided into two subgroups: sham-operated rats and rats subjected to cecal ligation and puncture (CLP).
In vivo cardiac mechanical function was examined, and mitochondria were harvested to determine their functional activity.
Oxidative stress was evaluated together with several factors involved in the regulation of reactive oxygen species metabolism.
Sepsis had little effect on cardiac mechanical function but strongly depressed mitochondrial function in the DEF group.
Conversely, dietary EPA greatly protected the mitochondria through a decreased oxidative stress of the mitochondrial matrix.
The latter was probably due to an increased uncoupling protein-3 expression, already seen in the sham-operated animals.
CLP rats in the EPA group also displayed increased mitochondrial sirtuin-3 protein expression that could reinforce the upholding of oxidative phosphorylation.
Dietary EPA preconditioned the heart against septic damage through several modifications that protect mitochondrial integrity.
This preconditioning can explain the cardioprotective effect of dietary EPA during sepsis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leger, Thibault& Azarnoush, K.& Traoré, Amidou& Cassagnes, Lucie& Rigaudière, Jean-Paul& Jouve, Chrystèle…[et al.]. 2019. Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1206585
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leger, Thibault…[et al.]. Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-21.
https://search.emarefa.net/detail/BIM-1206585
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leger, Thibault& Azarnoush, K.& Traoré, Amidou& Cassagnes, Lucie& Rigaudière, Jean-Paul& Jouve, Chrystèle…[et al.]. Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1206585
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206585
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر