PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma
المؤلفون المشاركون
Shi, Shunbin
Yu, Guiping
Huang, Bin
Mi, Yedong
Kang, Yan
Simon, Julia Pia
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Previous studies showed that PPAR-gamma (PPARG) ligands might serve as potential therapeutic agents for nonsmall cell lung cancer (NSCLC).
However, a few studies reported the specific relationship between PPARG and lung squamous cell carcinoma (LSCC).
Here, we made an effort to explore the relationship between PPARG and LSCC.
First, we used mega-analysis and partial mega-analysis to analyze the effects of PPARG on LSCC by using 12 independent LSCC expression datasets (285 healthy controls and 375 LSCC cases).
Then, literature-based molecular pathways between PPARG and LSCC were established.
After that, a gene set enrichment analysis (GSEA) was conducted to study the functionalities of PPARG and PPARG-driven triggers within the molecular pathways.
Finally, another mega-analysis was constructed to test the expression changes of PPARG and its driven targets.
The partial mega-analysis showed a significant downregulated expression of PPARG in LSCC (LFC=−1.08, p value=0.00073).
Twelve diagnostic markers and four prognostic markers were identified within multiple PPARG-LSCC regulatory pathways.
Our results suggested that the activation of PPARG expression may inhibit the development and progression of LSCC through the regulation of LSCC upstream regulators and downstream marker genes, which were involved in tumor cell proliferation and protein polyubiquitination/ubiquitination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Shunbin& Yu, Guiping& Huang, Bin& Mi, Yedong& Kang, Yan& Simon, Julia Pia. 2020. PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma. PPAR Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1206593
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Shunbin…[et al.]. PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma. PPAR Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1206593
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Shunbin& Yu, Guiping& Huang, Bin& Mi, Yedong& Kang, Yan& Simon, Julia Pia. PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma. PPAR Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1206593
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206593
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر