Ocoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma
المؤلفون المشاركون
Gargini, Ricardo
Hernández-SanMiguel, Esther
Cejalvo, Teresa
Segura-Collar, Berta
Núñez-Hervada, Paula
Hortigüela, Rafael
Sepúlveda-Sánchez, Juan M.
Hernández-Laín, Aurelio
Pérez-Núñez, Angel
Sanz, Eduardo
Sánchez-Gómez, Pilar
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-05
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Glioblastoma (GBM) is the most common and devastating primary brain tumor.
The presence of cancer stem cells (CSCs) has been linked to their therapy resistance.
Molecular and cellular components of the tumor microenvironment also play a fundamental role in the aggressiveness of these tumors.
In particular, high levels of hypoxia and reactive oxygen species participate in several aspects of GBM biology.
Moreover, GBM contains a large number of macrophages, which normally behave as immunosuppressive tumor-supportive cells.
In fact, the presence of both, hypoxia and M2-like macrophages, correlates with malignancy and poor prognosis in gliomas.
Antioxidant agents, as nutritional supplements, might have antitumor activity.
Ocoxin® oral solution (OOS), in particular, has anti-inflammatory and antioxidant properties, as well as antitumor properties in several neoplasia, without known side effects.
Here, we describe how OOS affects stem cell properties in certain GBMs, slowing down their tumor growth.
In parallel, OOS has a direct effect on macrophage polarization in vitro and in vivo, inhibiting the protumoral features of M2 macrophages.
Therefore, OOS could be a feasible candidate to be used in combination therapies during GBM treatment because it can target the highly resilient CSCs as well as their supportive immune microenvironment, without adding toxicity to conventional treatments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hernández-SanMiguel, Esther& Gargini, Ricardo& Cejalvo, Teresa& Segura-Collar, Berta& Núñez-Hervada, Paula& Hortigüela, Rafael…[et al.]. 2019. Ocoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1206614
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hernández-SanMiguel, Esther…[et al.]. Ocoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1206614
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hernández-SanMiguel, Esther& Gargini, Ricardo& Cejalvo, Teresa& Segura-Collar, Berta& Núñez-Hervada, Paula& Hortigüela, Rafael…[et al.]. Ocoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1206614
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206614
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر