Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel ExosomelncRNA MALAT1NF-κBTNF-α Signaling Pathway

الملخص EN

Aging is a risk factor for cardiovascular disease, and there is no effective therapeutic approach to alleviate this condition.

NF-κB and TNF-α have been implicated in the activation of the aging process, but the signaling molecules responsible for the inactivation of NF-κB and TNF-α remain unknown.

Exosomes have been reported to improve heart functions by releasing miRNA.

Recent studies suggest that lncRNAs are more tissue-specific and developmental stage-specific compared to miRNA.

However, the role of lncRNA in exosome-mediated cardiac repair has not been explored.

In the present study, we focused on metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), which is an lncRNA associated with cell senescence.

We discovered that human umbilical cord mesenchymal stem cell- (UMSC-) derived exosomes prevent aging-induced cardiac dysfunction.

Silencer RNA against lncRNA MALAT1 blocked the beneficial effects of exosomes.

In summary, we discovered that UMSC-derived exosomes prevent aging-induced cardiac dysfunction by releasing novel lncRNA MALAT1, which in turn inhibits the NF-κB/TNF-α signaling pathway.

These findings will lead to the development of therapies that delay aging and progression of age-related diseases.