Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel ExosomelncRNA MALAT1NF-κBTNF-α Signaling Pathway
المؤلفون المشاركون
Liu, Bin
Zhang, Yu
Zhang, Lulu
Yu, Xi-yong
Li, Yangxin
Zhu, Bao
Liang, Chun
Pan, Xiangbin
Wang, Yanli
Zhang, Yuqing
Xie, Wenping
Yan, Bing
Liu, Feng
Yip, Hon-Kan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-08
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Aging is a risk factor for cardiovascular disease, and there is no effective therapeutic approach to alleviate this condition.
NF-κB and TNF-α have been implicated in the activation of the aging process, but the signaling molecules responsible for the inactivation of NF-κB and TNF-α remain unknown.
Exosomes have been reported to improve heart functions by releasing miRNA.
Recent studies suggest that lncRNAs are more tissue-specific and developmental stage-specific compared to miRNA.
However, the role of lncRNA in exosome-mediated cardiac repair has not been explored.
In the present study, we focused on metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), which is an lncRNA associated with cell senescence.
We discovered that human umbilical cord mesenchymal stem cell- (UMSC-) derived exosomes prevent aging-induced cardiac dysfunction.
Silencer RNA against lncRNA MALAT1 blocked the beneficial effects of exosomes.
In summary, we discovered that UMSC-derived exosomes prevent aging-induced cardiac dysfunction by releasing novel lncRNA MALAT1, which in turn inhibits the NF-κB/TNF-α signaling pathway.
These findings will lead to the development of therapies that delay aging and progression of age-related diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Bao& Zhang, Lulu& Liang, Chun& Liu, Bin& Pan, Xiangbin& Wang, Yanli…[et al.]. 2019. Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel ExosomelncRNA MALAT1NF-κBTNF-α Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1206624
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Bao…[et al.]. Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel ExosomelncRNA MALAT1NF-κBTNF-α Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1206624
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Bao& Zhang, Lulu& Liang, Chun& Liu, Bin& Pan, Xiangbin& Wang, Yanli…[et al.]. Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel ExosomelncRNA MALAT1NF-κBTNF-α Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1206624
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206624
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر