Fasting Whole-Body Energy Homeostasis and Hepatic Energy Metabolism in Nondiabetic Humans with Fatty Liver
المؤلفون المشاركون
Del Maschio, Alessandro
De Cobelli, Francesco
Castoldi , Giovanna
Lattuada, Guido
Radaelli, Maria Grazia
Manzoni, Giuseppina
Perra, Silvia
Perseghin, Gianluca
Esposito, Antonio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Fatty liver is believed to be sustained by a higher than normal adipose-derived NEFA flux to the liver.
Also, hepatic energy metabolism may be a rate-limiting step of intrahepatic fat (IHF) accumulation.
Aims.
To assess whole-body energy metabolism and hepatic high-energy phosphates (HEPs) in individuals with fatty liver.
Methods.
We studied 22 individuals with fatty liver and 22 control individuals matched for anthropometric features by means of (1) hepatic 1H-magnetic resonance spectroscopy (MRS) to measure the IHF content, (2) hepatic 31P-MRS to assess the relative content of HEPs (phosphomonoesters, phosphodiesters, inorganic phosphorus, and ATP), and (3) indirect calorimetry to assess whole-body resting energy expenditure and substrate oxidation.
Results.
Patients with newly diagnosed fatty liver and controls were not different for anthropometric parameters.
Based on HOMA2%-S, individuals with fatty liver were more insulin resistant than controls.
Resting energy expenditure and the pattern of substrate oxidation were not different between groups.
Relative content of HEPs was not different between groups; in particular, the Pi/γ-ATP ratio, the most important signals in terms of monitoring energy homeostasis, was not different even if it was associated with indirect calorimetry-derived parameters of oxidative substrate disposal.
Conclusions.
These data demonstrate that fasting whole-body energy metabolism and the relative content of HEPs in nondiabetic patients with fatty liver are not different than those in controls when they are matched for anthropometric features.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lattuada, Guido& Radaelli, Maria Grazia& De Cobelli, Francesco& Esposito, Antonio& Manzoni, Giuseppina& Perra, Silvia…[et al.]. 2019. Fasting Whole-Body Energy Homeostasis and Hepatic Energy Metabolism in Nondiabetic Humans with Fatty Liver. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1206647
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lattuada, Guido…[et al.]. Fasting Whole-Body Energy Homeostasis and Hepatic Energy Metabolism in Nondiabetic Humans with Fatty Liver. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1206647
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lattuada, Guido& Radaelli, Maria Grazia& De Cobelli, Francesco& Esposito, Antonio& Manzoni, Giuseppina& Perra, Silvia…[et al.]. Fasting Whole-Body Energy Homeostasis and Hepatic Energy Metabolism in Nondiabetic Humans with Fatty Liver. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1206647
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206647
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر