Incidence of Second Primary Malignancies in Patients with Castration-Resistant Prostate Cancer: An Observational Retrospective Cohort Study in the United States
المؤلفون المشاركون
Kaye, James A.
Saltus, Catherine W.
Vassilev, Zdravko P.
Zong, Jihong
Calingaert, Brian
Andrews, Elizabeth B.
Soriano-Gabarró, Montse
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
New therapies for castration-resistant prostate cancer (CRPC) may be associated with increased risk of second primary malignancies (SPM).
We therefore estimated the population-based incidence of SPM among patients with CRPC in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database.
We also estimated the proportion of men with CRPC with bone metastases and overall survival.
Methods.
We conducted a retrospective cohort study of United States (US) men aged ≥ 65 years with CRPC.
Cohort entry was from January 1, 2000, to December 31, 2011, with follow-up through December 31, 2013.
Castration resistance was defined by treatment with second-line systemic therapy (after surgical or medical castration).
SPM were diagnoses of primary cancers (other than prostate) in SEER or Medicare data.
Results.
Altogether 2,234 patients met eligibility criteria.
Most (1,887; 84.5%) had evidence of bone metastases in Medicare claims.
SPM occurred in 172 patients (incidence rate 5.9 per 100 person-years; 95% confidence interval [CI], 5.0-6.8; standardized incidence ratio = 3.1, 95% CI, 2.8-3.6, based on SEER incidence rate of all malignancies except prostate cancer among men aged ≥ 65 years).
The most common SPM were lung/bronchus (n = 29, 16.9%), urinary bladder (n = 22, 12.8%), and colon/rectum (n = 21, 12.2%).
Median survival was 1.2 years (95% CI, 1.1-1.3); 5-year survival was 9% (95% CI, 7-11%).
Conclusions.
This study provides the first estimate of SPM risk in older men with CRPC in the US.
The incidence rate is approximately threefold higher than the population-based cancer incidence among men without prostate cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saltus, Catherine W.& Vassilev, Zdravko P.& Zong, Jihong& Calingaert, Brian& Andrews, Elizabeth B.& Soriano-Gabarró, Montse…[et al.]. 2019. Incidence of Second Primary Malignancies in Patients with Castration-Resistant Prostate Cancer: An Observational Retrospective Cohort Study in the United States. Prostate Cancer،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1206800
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saltus, Catherine W.…[et al.]. Incidence of Second Primary Malignancies in Patients with Castration-Resistant Prostate Cancer: An Observational Retrospective Cohort Study in the United States. Prostate Cancer No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1206800
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saltus, Catherine W.& Vassilev, Zdravko P.& Zong, Jihong& Calingaert, Brian& Andrews, Elizabeth B.& Soriano-Gabarró, Montse…[et al.]. Incidence of Second Primary Malignancies in Patients with Castration-Resistant Prostate Cancer: An Observational Retrospective Cohort Study in the United States. Prostate Cancer. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1206800
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206800
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر