Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease
المؤلفون المشاركون
Liu, Chunfeng
Liu, Jiang-bing
Leng, Jun-ling
Wang, Ying-ge
Zhang, Yu
Tang, Tie-yu
Tao, Li-hong
Zhang, Xin-jiang
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson’s disease (PD).
The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS.
Objective.
To delineate NMS in FDR of patients with different clinical types of PD.
Methods.
A total of 98 PD probands were recruited; 256 siblings of them were enrolled in the FDR group.
Various scales were used to assess NMS, including depression, anxiety, cognitive impairment, insomnia, constipation, excessive daytime sleepiness, rapid eye movement sleep behavior disorder (RBD), and restless legs syndrome (RLS).
The incidences of NMS were further compared between the FDR groups of PD with different types.
Results.
The FDR of early-onset PD (EOP) showed a higher incidence of moderate to severe depression (OR = 4.08; 95% CI: 1.12–14.92; P=0.033), anxiety (OR = 4.22; 95% CI: 1.87–9.52; P=0.001), and excessive daytime sleepiness (OR = 3.40; 95% CI: 1.00–11.48; P=0.049) than the FDR of late-onset PD (LOP).
It was also found that RBD (OR = 11.65; 95% CI: 3.82–35.54; P<0.001), constipation (OR = 4.94; 95% CI: 1.85–13.21; P=0.001), sleep disorders (OR = 4.51; 95% CI: 1.73–11.78; P=0.002), cognitive impairment (OR = 3.55; 95% CI: 1.62–7.77; P=0.002), and anxiety (OR = 2.49; 95% CI: 1.32–4.71; P=0.005) were more frequent in FDR of tremor-dominant PD (TDP) than in FDR of non-tremor-dominant PD (NTDP).
Conclusions.
The siblings of patients with EOP and TDP have more NMS, presuming that they have a higher risk in the PD prodromal stage.
Whether they have a greater possibility to progress into PD requires further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Jiang-bing& Leng, Jun-ling& Wang, Ying-ge& Zhang, Yu& Tang, Tie-yu& Tao, Li-hong…[et al.]. 2019. Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1206836
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Jiang-bing…[et al.]. Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease. Parkinson’s Disease No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1206836
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Jiang-bing& Leng, Jun-ling& Wang, Ying-ge& Zhang, Yu& Tang, Tie-yu& Tao, Li-hong…[et al.]. Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1206836
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206836
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر