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Prevalence and Risk Factors for Opioid-Induced Constipation in an Older National Veteran Cohort
المؤلفون المشاركون
Cao, Ai-Ze
Matheny, Michael E.
FitzHenry, Fern
Eden, Svetlana K.
Denton, Jason
Cao, Hui
Reeves, Ruth
Chen, Guanhua
Gobbel, Glenn
Wells, Nancy
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objectives.
This research describes the prevalence and covariates associated with opioid-induced constipation (OIC) in an observational cohort study utilizing a national veteran cohort and integrated data from the Center for Medicare and Medicaid Services (CMS).
Methods.
A cohort of 152,904 veterans with encounters between 1 January 2008 and 30 November 2010, an exposure to opioids of 30 days or more, and no exposure in the prior year was developed to establish existing conditions and medications at the start of the opioid exposure and determining outcomes through the end of exposure.
OIC was identified through additions/changes in laxative prescriptions, all-cause constipation identification through diagnosis, or constipation related procedures in the presence of opioid exposure.
The association of time to constipation with opioid use was analyzed using Cox proportional hazard regression adjusted for patient characteristics, concomitant medications, laboratory tests, and comorbidities.
Results.
The prevalence of OIC was 12.6%.
Twelve positively associated covariates were identified with the largest associations for prior constipation and prevalent laxative (any laxative that continued into the first day of opioid exposure).
Among the 17 negatively associated covariates, the largest associations were for erythromycins, androgens/anabolics, and unknown race.
Conclusions.
There were several novel covariates found that are seen in the all-cause chronic constipation literature but have not been reported for opioid-induced constipation.
Some are modifiable covariates, particularly medication coadministration, which may assist clinicians and researchers in risk stratification efforts when initiating opioid medications.
The integration of CMS data supports the robustness of the analysis and may be of interest in the elderly population warranting future examination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
FitzHenry, Fern& Eden, Svetlana K.& Denton, Jason& Cao, Hui& Cao, Ai-Ze& Reeves, Ruth…[et al.]. 2020. Prevalence and Risk Factors for Opioid-Induced Constipation in an Older National Veteran Cohort. Pain Research and Management،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1206847
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
FitzHenry, Fern…[et al.]. Prevalence and Risk Factors for Opioid-Induced Constipation in an Older National Veteran Cohort. Pain Research and Management No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1206847
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
FitzHenry, Fern& Eden, Svetlana K.& Denton, Jason& Cao, Hui& Cao, Ai-Ze& Reeves, Ruth…[et al.]. Prevalence and Risk Factors for Opioid-Induced Constipation in an Older National Veteran Cohort. Pain Research and Management. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1206847
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206847
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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