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Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review
المؤلفون المشاركون
Feder, David
Camargo Maluf, Fauze
Alves de Siqueira Carvalho, Alzira
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
In the early sixties, a discussion started regarding the association between Parkinson’s disease (PD) and type II diabetes mellitus (T2DM).
Today, this potential relationship is still a matter of debate.
This review aims to analyze both diseases concerning causal relationships and treatments.
A total of 104 articles were found, and studies on animal and “in vitro” models showed that T2DM causes neurological alterations that may be associated with PD, such as deregulation of the dopaminergic system, a decrease in the expression of peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), an increase in the expression of phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes 15 (PED/PEA-15), and neuroinflammation, as well as acceleration of the formation of alpha-synuclein amyloid fibrils.
In addition, clinical studies described that Parkinson’s symptoms were notably worse after the onset of T2DM, and seven deregulated genes were identified in the DNA of T2DM and PD patients.
Regarding treatment, the action of antidiabetic drugs, especially incretin mimetic agents, seems to confer certain degree of neuroprotection to PD patients.
In conclusion, the available evidence on the interaction between T2DM and PD justifies more robust clinical trials exploring this interaction especially the clinical management of patients with both conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Camargo Maluf, Fauze& Feder, David& Alves de Siqueira Carvalho, Alzira. 2019. Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1206916
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Camargo Maluf, Fauze…[et al.]. Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review. Parkinson’s Disease No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1206916
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Camargo Maluf, Fauze& Feder, David& Alves de Siqueira Carvalho, Alzira. Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1206916
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206916
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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