Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County
المؤلفون المشاركون
Mielke, Michelle M.
Savica, Rodolfo
Hasan, Shemonti
Ahlskog, J. Eric
Bower, James
Turcano, Pierpaolo
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
Autonomic symptoms are common in α-synuclein disorders: multiple system atrophy (MSA), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and Parkinson’s disease with dementia (PDD).
These symptoms may precede the motor findings/clinical diagnosis by years.
Erectile dysfunction (ED) is an autonomic symptom that has rarely been studied in these α-synuclein disorders.
In this population-based, case-control study, we investigated the association between premonitory erectile dysfunction surfacing prior to the clinical-motor manifestations of these α-synucleinopathies.
Methods.
We used the medical record-linkage system of the Rochester Epidemiology Project to identify cases of α-synucleinopathies in Olmsted County from 1991 to 2010.
Each male case was matched by age (±1 year) of symptom onset and sex to a control.
We reviewed complete medical records of cases and controls to detect erectile dysfunction prior to the clinical-motor onset of α-synucleinopathies of any type.
We used conditional logistic regression to calculate the odds ratio of all α-synucleinopathies, as well as by type, adjusting for diabetes, coffee, and smoking.
Results.
A history of male erectile dysfunction was associated with 1.5-fold increased odds of an α-synucleinopathy diagnosis of any type in univariate analyses (p=0.06).
When stratifying α-synucleinopathies by type, early erectile dysfunction was most frequent in MSA cases than matched controls (45% vs.
9%).
Premotor phase ED was next most frequent among the DLB cases (46% vs.
27% among the controls; OR = 2.83, p=0.03; when adjusted for diabetes, smoking, and coffee, OR = 2.98, p=0.04).
Premotor phase ED was not significantly associated with PD or PDD.
Conclusions.
Early erectile dysfunction may be a premotor symptom of MSA and DLB, reflecting premonitory dysautonomia.
It was not associated with premotor PD or PDD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hasan, Shemonti& Mielke, Michelle M.& Ahlskog, J. Eric& Bower, James& Turcano, Pierpaolo& Savica, Rodolfo. 2019. Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1206958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hasan, Shemonti…[et al.]. Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County. Parkinson’s Disease No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1206958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hasan, Shemonti& Mielke, Michelle M.& Ahlskog, J. Eric& Bower, James& Turcano, Pierpaolo& Savica, Rodolfo. Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1206958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر