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Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County
المؤلفون المشاركون
Mielke, Michelle M.
Savica, Rodolfo
Hasan, Shemonti
Ahlskog, J. Eric
Bower, James
Turcano, Pierpaolo
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
Autonomic symptoms are common in α-synuclein disorders: multiple system atrophy (MSA), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and Parkinson’s disease with dementia (PDD).
These symptoms may precede the motor findings/clinical diagnosis by years.
Erectile dysfunction (ED) is an autonomic symptom that has rarely been studied in these α-synuclein disorders.
In this population-based, case-control study, we investigated the association between premonitory erectile dysfunction surfacing prior to the clinical-motor manifestations of these α-synucleinopathies.
Methods.
We used the medical record-linkage system of the Rochester Epidemiology Project to identify cases of α-synucleinopathies in Olmsted County from 1991 to 2010.
Each male case was matched by age (±1 year) of symptom onset and sex to a control.
We reviewed complete medical records of cases and controls to detect erectile dysfunction prior to the clinical-motor onset of α-synucleinopathies of any type.
We used conditional logistic regression to calculate the odds ratio of all α-synucleinopathies, as well as by type, adjusting for diabetes, coffee, and smoking.
Results.
A history of male erectile dysfunction was associated with 1.5-fold increased odds of an α-synucleinopathy diagnosis of any type in univariate analyses (p=0.06).
When stratifying α-synucleinopathies by type, early erectile dysfunction was most frequent in MSA cases than matched controls (45% vs.
9%).
Premotor phase ED was next most frequent among the DLB cases (46% vs.
27% among the controls; OR = 2.83, p=0.03; when adjusted for diabetes, smoking, and coffee, OR = 2.98, p=0.04).
Premotor phase ED was not significantly associated with PD or PDD.
Conclusions.
Early erectile dysfunction may be a premotor symptom of MSA and DLB, reflecting premonitory dysautonomia.
It was not associated with premotor PD or PDD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hasan, Shemonti& Mielke, Michelle M.& Ahlskog, J. Eric& Bower, James& Turcano, Pierpaolo& Savica, Rodolfo. 2019. Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1206958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hasan, Shemonti…[et al.]. Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County. Parkinson’s Disease No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1206958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hasan, Shemonti& Mielke, Michelle M.& Ahlskog, J. Eric& Bower, James& Turcano, Pierpaolo& Savica, Rodolfo. Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1206958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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