Kinematic Metrics from a Wireless Stylus Quantify Tremor and Bradykinesia in Parkinson’s Disease
المؤلفون المشاركون
Alberts, Jay L.
Machado, A. G.
Maldonado-Naranjo, Andres
Koop, Mandy Miller
Hogue, Olivia
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
A fundamental challenge in the clinical care of Parkinson disease (PD) is the current dependence on subjective evaluations of tremor and bradykinesia.
New technologies offer the ability to evaluate motor deficits using purely objective measures.
The aim of this study was to develop and evaluate the efficacy of a wireless stylus (Cleveland Clinic Stylus) with an embedded motion sensor to quantitatively assess tremor and bradykinesia in patients with PD with subthalamic nucleus (STN) deep brain stimulation (DBS).
Twenty-one subjects were tested in various on and off DBS conditions while holding the Cleveland Clinic Stylus while at rest, maintaining a postural hold, and during a movement task.
Kinematic metrics were calculated from the motion sensor data, including 3D angular velocity and 3D acceleration data, and were compared between the on and off conditions.
Generalized estimating equations (GEEs) were used to determine the relationship between kinematic metrics and MDS-Unified Parkinson’s Disease Rating Scale Motor III (UPDRS-III) subscores.
Kinematic metrics from the rest and postural tasks were significantly related to the UPDRS-III subscores of tremor (p<0.001 for all metrics), and kinematic metrics from the movement task were significantly related to the UPDRS-III subscore of bradykinesia (p<0.001 for 3/7 metrics).
Kinematic metrics (7/9) showed a significant effect of stimulation setting (range: p<0.03–<0.0001) across the three tasks, indicating significant improvements from DBS in these measures.
The Cleveland Clinic Stylus provided quantitative kinematic measures of tremor and bradykinesia severity and detected significant improvements in these measures from medication and DBS therapy.
This low-cost, easy-to-use tool can provide objective measures that will improve clinical care of PD patients by providing a more reliable and objective evaluation of movement symptoms, disease progression, and effects of therapy in and outside the clinical setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maldonado-Naranjo, Andres& Koop, Mandy Miller& Hogue, Olivia& Alberts, Jay L.& Machado, A. G.. 2019. Kinematic Metrics from a Wireless Stylus Quantify Tremor and Bradykinesia in Parkinson’s Disease. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1206995
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maldonado-Naranjo, Andres…[et al.]. Kinematic Metrics from a Wireless Stylus Quantify Tremor and Bradykinesia in Parkinson’s Disease. Parkinson’s Disease No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1206995
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maldonado-Naranjo, Andres& Koop, Mandy Miller& Hogue, Olivia& Alberts, Jay L.& Machado, A. G.. Kinematic Metrics from a Wireless Stylus Quantify Tremor and Bradykinesia in Parkinson’s Disease. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1206995
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206995
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر