Atrophic Myenteric and Submucosal Neurons Are Observed in Parkinson’s Disease
المؤلفون المشاركون
Englund, Elisabet
Ohlsson, Bodil
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Aim.
Parkinson’s disease is often accompanied by gastrointestinal symptoms, especially constipation.
Microscopic studies of the enteric nervous system and enteric neuropathy have often been performed by immunostaining in the myenteric plexa.
The aim of the present study was to examine whether pathologic changes could be identified by conventional hematoxylin and eosin (H&E) staining and could also be seen in the submucosal plexa.
Materials and Methods.
In 20 deceased cases (11 male/9 female) of Parkinson’s disease, the intestinal tract was investigated for potential neuroganglionic disease.
Ten cases (7 male/3 female) of non-Parkinson, intestinally asymptomatic individuals were used as controls.
Specimens from the jejunum and colon were sampled.
The material was treated with standard histopathological procedures, i.e., fixed in formaldehyde solution, dehydrated and embedded in paraffin, sectioned at 5 μm thickness, and stained with H&E and immunostaining for α-synuclein.
Results.
In 15 cases (7 male/8 female) of Parkinson’s disease, atrophic/pycnotic nerve plexus cells were present, i.e., signs of ganglionic degeneration in the submucosal and/or myenteric plexa, mostly identified in both loci, by H&E staining.
In some cases, the degenerative signs were mild, however, corroborated by findings of α-synuclein deposits in the ganglion cells.
The remaining 5 cases showed no signs of degeneration in the H&E staining, but immunostaining revealed minimal α-synuclein deposits in 3 cases.
None of the controls showed any ganglionic degeneration/α-synuclein deposits.
Conclusion.
It seems possible to identify a morphologic intestinal disease substrate in Parkinson’s disease by H&E staining, showing ganglion cell pycnosis and degeneration in both plexa.
This finding may indicate a potential to diagnose enteric neuropathy in highly accessible sites.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ohlsson, Bodil& Englund, Elisabet. 2019. Atrophic Myenteric and Submucosal Neurons Are Observed in Parkinson’s Disease. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1207009
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ohlsson, Bodil& Englund, Elisabet. Atrophic Myenteric and Submucosal Neurons Are Observed in Parkinson’s Disease. Parkinson’s Disease No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1207009
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ohlsson, Bodil& Englund, Elisabet. Atrophic Myenteric and Submucosal Neurons Are Observed in Parkinson’s Disease. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1207009
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207009
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر