Assessment of Real-Life Outcomes in Schizophrenia Patients according to Compliance

الملخص EN

Objective.

To describe and compare demographics, outcomes and comorbidities in schizophrenia patients by treatment compliance.

Methods.

This was a cross-sectional survey of hospital- or office-based psychiatrists who saw ≥6 schizophrenia patients per week and were responsible for treatment decisions.

Recruited physicians completed a patient record form (PRF) for their first 10 consulted schizophrenia patients aged ≥18.

These patients voluntarily completed a patient self-completion form (PSC).

Compliance was measured by subjective physician assessment.

Drivers of and outcomes associated with compliance were identified by regression analyses.

Results.

A total of 150 physicians completed PRFs for 1489 patients (706 sometimes compliant (SC), 636 always compliant (AC)).

A total of 680 patients completed a PSC (327 SC, 295 AC).

AC patients were less likely to be male (52.2% vs.

58.6%; P=0.021) and unemployed (odds ratio (OR) 0.91, 95% confidence interval (CI) 0.82–1.00; P<0.001) or to have had a treatment regimen change (OR 0.56, 95% CI 0.40–0.80; P=0.001) than SC patients.

AC patients were less likely to have had more comorbidities (OR 0.91, 95% CI 0.82–1.00; P=0.045) and hospitalizations in the past 12 months (OR 0.59, 95% CI 0.43–0.80; P=0.001) than SC patients.

Overall, AC patients had better clinical and humanistic outcomes.

Weight gain was a common side effect for all patients; SC patients with weight gain had poorer outcomes than those without weight gain.

Conclusion.

Schizophrenia patients that were SC experienced poorer clinical outcomes and quality of life.

Weight gain may exacerbate these poorer outcomes.