Peroxisome Proliferator-Activated Receptor- γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p
المؤلفون المشاركون
Zou, Yunzeng
Sun, Aijun
Xu, Lei
Ge, Junbo
Zhu, Hong
Zhao, Gang
Wang, Shijun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is one of the major receptors expressed on the endothelium of arterial wall with a key role in endothelial dysfunction and the development of atherosclerosis.
Recent evidence suggested that LOX-1 is upregulated under the condition of insulin resistance and could be suppressed by the antidiabetic drugs.
We previously also confirmed that Thiazolidinedione (TZD) has the inhibitory effect on LOX-1 in ox-LDL-induced endothelial cells.
However, the underlying mechanism is unclear.
Here we showed that Rosiglitazone treatment significantly attenuated the expressions of LOX-1, ICAM-1, VCAM-1, p 4 7 p h o x , and the atherosclerotic lesions in ApoE-/- mice with high-fat diet.
In vitro, we revealed that Rosiglitazone inhibited LOX-1 by regulating miR-590-5p.
Ox-LDL-mediated ICAM-1, VCAM-1, and p 4 7 p h o x were significantly reduced by Rosiglitazone, but all reversed after pretreating the cells with antagomiR-590-5p.
Induction with Rosiglitazone activated PPAR-γ and promoted its nuclear translocation in cultured human umbilical vein endothelial cells (HUVECs).
The nuclear PPAR-γ upregulated the miR-590-5p level through binding to its transcriptional promoter region.
Retaining PPAR-γ in cytoplasm by transfecting with P P A R - γ ⊿ N L S plasmid in HUVECs failed to activate miR-590-5p.
Mutation of the promoter region of PPAR-γ also reduced the miR-590-5p promoter luciferase activity.
Collectively, these data indicated that PPAR-γ may have the therapeutic potential in atherosclerosis via the transcriptional regulation of miR-590-5p in endothelial cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Lei& Zhao, Gang& Zhu, Hong& Wang, Shijun& Sun, Aijun& Zou, Yunzeng…[et al.]. 2019. Peroxisome Proliferator-Activated Receptor- γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p. PPAR Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1207118
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Lei…[et al.]. Peroxisome Proliferator-Activated Receptor- γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p. PPAR Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1207118
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Lei& Zhao, Gang& Zhu, Hong& Wang, Shijun& Sun, Aijun& Zou, Yunzeng…[et al.]. Peroxisome Proliferator-Activated Receptor- γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p. PPAR Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1207118
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207118
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر