![](/images/graphics-bg.png)
SkinMuscle Incision and Retraction Induces Evoked and Spontaneous Pain in Mice
المؤلفون المشاركون
Feng, Zhiying
Yang, Juan
Yuan, Fei
Ye, Gang
Wang, Yong-Jie
Wu, Cheng
Wang, Jinghua
Li, Xiang-Yao
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Surgery is a frequent cause of persistent pain.
Unrelieved chronic postsurgical pain causes unnecessary patient suffering and discomfort and usually leads to psychological complications.
The rat model of skin/muscle incision and retraction (SMIR) with decreased paw withdrawal thresholds developed by Flatters was usually used to investigate the underlying mechanism of chronic postsurgical pain.
Objectives.
The aim of our study was to develop a new mice model of SMIR for further investigation with transgenic mice and so on and to evaluate the analgesic effects of clonidine and gabapentin on pain behavior with this new mice model.
Methods.
Male C57BL/6 mice were anesthetized, and a 1.0–1.3 cm incision was made in the skin of the medial thigh approximately 3 mm medial to the saphenous vein to reveal the muscle of the thigh.
The paw withdrawal threshold (PWT) to mechanical stimuli and the paw withdrawal latency to heat stimuli were measured before and after SMIR.
Furthermore, the PWT to mechanical stimuli and conditioned place preference (CPP) was measured before and after the systemic injection of clonidine and gabapentin.
Results.
SMIR-evoked mechanical hypersensitivity in mice began on day 1 after the procedure, prominent between days 1 and 10 after the procedure, persisted at least until day 14, and disappeared on day 18 after the procedure.
However, the mice model of SMIR did not evoke significant heat hypersensitivity.
Systemic injection of clonidine and gabapentin raised the PWT in the SMIR mice dose-dependently.
Compared with the mice that underwent the sham operation, mice of SMIR spent a longer time in the clonidine-paired chamber than those of NS, while the gabapentin-paired chamber has no difference with that of NS in the CPP paradigm.
Conclusion.
These data suggested that the mice model of SMIR demonstrated a persistent pain syndrome, including evoked pain and spontaneous pain.
Clonidine and gabapentin could relieve mechanical hypersensitivity dose-dependently simultaneously.
However, clonidine but not gabapentin could alleviate the spontaneous pain of SMIR in the mice model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Juan& Yuan, Fei& Ye, Gang& Wang, Yong-Jie& Wu, Cheng& Wang, Jinghua…[et al.]. 2019. SkinMuscle Incision and Retraction Induces Evoked and Spontaneous Pain in Mice. Pain Research and Management،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1207319
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Juan…[et al.]. SkinMuscle Incision and Retraction Induces Evoked and Spontaneous Pain in Mice. Pain Research and Management No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1207319
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Juan& Yuan, Fei& Ye, Gang& Wang, Yong-Jie& Wu, Cheng& Wang, Jinghua…[et al.]. SkinMuscle Incision and Retraction Induces Evoked and Spontaneous Pain in Mice. Pain Research and Management. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1207319
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207319
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)