Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma
المؤلفون المشاركون
Michalek, Joel E.
Keller, Charles
Berlow, Noah E.
Grasso, Catherine S.
Quist, Michael J.
Cheng, Mingshan
Gandour-Edwards, Regina
Hernandez, Brian S.
Spellman, Paul
Renneker, Mark
Ryan, Christopher W.
Pal, Ranadip
Million, Lynn
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Nonrhabdomyosarcoma soft-tissue sarcomas (STSs) are a class of 50+ cancers arising in muscle and soft tissues of children, adolescents, and adults.
Rarity of each subtype often precludes subtype-specific preclinical research, leaving many STS patients with limited treatment options should frontline therapy be insufficient.
When clinical options are exhausted, personalized therapy assignment approaches may help direct patient care.
Here, we report the results of an adult female STS patient with relapsed undifferentiated pleomorphic sarcoma (UPS) who self-drove exploration of a wide array of personalized Clinical Laboratory Improvement Amendments (CLIAs) level and research-level diagnostics, including state of the art genomic, proteomic, ex vivo live cell chemosensitivity testing, a patient-derived xenograft model, and immunoscoring.
Her therapeutic choices were also diverse, including neoadjuvant chemotherapy, radiation therapy, and surgeries.
Adjuvant and recurrence strategies included off-label and natural medicines, several immunotherapies, and N-of-1 approaches.
Identified treatment options, especially those validated during the in vivo study, were not introduced into the course of clinical treatment but did provide plausible treatment regimens based on FDA-approved clinical agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Berlow, Noah E.& Grasso, Catherine S.& Quist, Michael J.& Cheng, Mingshan& Gandour-Edwards, Regina& Hernandez, Brian S.…[et al.]. 2020. Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma. Complexity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1207330
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Berlow, Noah E.…[et al.]. Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma. Complexity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1207330
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Berlow, Noah E.& Grasso, Catherine S.& Quist, Michael J.& Cheng, Mingshan& Gandour-Edwards, Regina& Hernandez, Brian S.…[et al.]. Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma. Complexity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1207330
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207330
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر