Flufenamic Acid Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells by Antagonizing the PI3KAKT Signaling Pathway
المؤلفون المشاركون
Wang, Siyi
Xia, Dandan
Zhu, Yuan
Gu, Ranli
Liu, Xuenan
Liu, Yunsong
Zhou, Yongsheng
Li, Zheng
Liu, Hao
Zhang, Ping
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-16
دولة النشر
مصر
عدد الصفحات
12
الملخص EN
Objectives.
Flufenamic acid (FFA) is a representative of the fenamic acids, an important group of NSAIDs.
In the present study, we study the effects of FFA on adipogenesis of human mesenchymal stem cells (MSCs) and we explore the potential mechanism.
Methods.
To investigate the effects of FFA on adipogenic differentiation of hMSCs, human adipose-derived stem cells (hASCs) and human bone marrow mesenchymal stem cells (hBMMSCs), representative of hMSCs, were treated with FFA during adipogenic differentiation in vitro.
The effects of FFA in vivo were evaluated using a heterotopic adipose formation assay in nude mice as well as ovariectomized (OVX) and aged mice.
To explore the mechanism of FFA, Western blot was used to determine activation of the PI3K/AKT signaling pathway.
Results.
Our results demonstrate that, at certain concentrations, FFA inhibited adipogenesis of human MSCs both in vitro and in vivo.
Mechanistically, FFA inhibited adipogenesis of human MSCs by inhibiting the PI3K/AKT pathway.
Conclusions.
The present study indicated that FFA could be used to inhibit adipogenesis of human MSCs in tissue engineering and diseases related to excessive adipogenic differentiation of MSCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xuenan& Li, Zheng& Liu, Hao& Zhu, Yuan& Xia, Dandan& Wang, Siyi…[et al.]. 2020. Flufenamic Acid Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells by Antagonizing the PI3KAKT Signaling Pathway. Stem Cells International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1207610
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xuenan…[et al.]. Flufenamic Acid Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells by Antagonizing the PI3KAKT Signaling Pathway. Stem Cells International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1207610
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xuenan& Li, Zheng& Liu, Hao& Zhu, Yuan& Xia, Dandan& Wang, Siyi…[et al.]. Flufenamic Acid Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells by Antagonizing the PI3KAKT Signaling Pathway. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1207610
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207610
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر