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Global Dynamics of a Virus-Immune System with Virus-Guided Therapy and Saturation Growth of Virus
المؤلفون المشاركون
المصدر
Mathematical Problems in Engineering
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-09
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
We considered a piecewise virus-immune dynamic model to investigate the effectiveness of the HIV virus loads-guided structured treatment interruptions (STIs).
To better describe the biological reality, we extended the existing models by taking the carrying capacity of the virus loads into consideration to indicate the saturated growth of virus loads.
We initially investigated the sliding dynamics of the proposed model and then obtained the global dynamics of the proposed model.
Our main results showed that the system can exhibit very complex and diverse dynamic behaviors including a globally asymptotically stable equilibrium, bistable equilibra, and tristable equilibria, depending on the dynamics of the subsystems and the threshold level.
In particular, an interesting result indicated that, with a proper threshold condition, the virus-guided therapy policy can successfully control the virus loads far below its carrying capacity and maintain the activity of the immune system for the case that the effector cells always go to zero without therapy or with continuous therapy.
The finding suggested that the optimal strategy should be individual-based due to coexistence of multiple stable steady states, depending on the threshold conditions and the initial levels of viral loads and effector cells of the patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Qian& Xiao, Yanni. 2018. Global Dynamics of a Virus-Immune System with Virus-Guided Therapy and Saturation Growth of Virus. Mathematical Problems in Engineering،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1207631
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Qian& Xiao, Yanni. Global Dynamics of a Virus-Immune System with Virus-Guided Therapy and Saturation Growth of Virus. Mathematical Problems in Engineering No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1207631
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Qian& Xiao, Yanni. Global Dynamics of a Virus-Immune System with Virus-Guided Therapy and Saturation Growth of Virus. Mathematical Problems in Engineering. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1207631
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207631
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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