Curcumin-Activated Mesenchymal Stem Cells Derived from Human Umbilical Cord and Their Effects on MPTP-Mouse Model of Parkinson’s Disease: A New Biological Therapy for Parkinson’s Disease
المؤلفون المشاركون
Li, Jin-Feng
Liu, Xin-Shan
Wang, Shan-Shan
Xiaopeng, Yang
Xue, Peng
Zeng, Zhi-Lei
Zhang, Si-Miao
Zheng, Wei
Hua, Linlin
Wang, Hai-Tao
Guo, Shang
Wang, Yunliang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-17
دولة النشر
مصر
عدد الصفحات
17
الملخص EN
Background.
The aim of this study was to investigate the effects of human umbilical cord mesenchymal stem cell activated by curcumin (hUC-MSCs-CUR) on Parkinson’s disease (PD).
hUC-MSCs can differentiate into many types of adult tissue cells including dopaminergic (DA) neurons.
CUR could protect DA neurons from apoptosis induced by 6-hydroxydopamine (6-OHDA).
Therefore, we used the hUC-MSCs activated by CUR for the treatment of PD in an animal model.
Methods.
The hUC-MSCs-CUR was transplanted into the MPTP-induced PD mouse models via the tail vein.
We found that hUC-MSCs-CUR significantly improved the motor ability, increased the tyrosine hydroxylase (TH), dopamine (DA), and Bcl-2 levels, and reduced nitric oxide synthase, Bax, and cleaved caspase 3 expression in PD mice.
The supernatant of hUC-MSCs-CUR (CM-CUR) was used to stimulate the SH-SY5Y cellular model of PD; cell proliferation, differentiation, TH, and neuronal-specific marker microtubular-associated protein 2 (MAP2) expressions were examined.
Results.
Our data showed that CM-CUR significantly promoted cell proliferation and gradually increased TH and MAP2 expression in SH-SY5Y PD cells.
The beneficial effects could be associated with significant increase of rough endoplasmic reticulum in the hUC-MSCs-CUR, which secretes many cytokines and growth factors beneficial for PD treatment.
Conclusions.
Transplantation of hUC-MSCs-CUR could show promise for improving the motor recovery of PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yunliang& Liu, Xin-Shan& Wang, Shan-Shan& Xue, Peng& Zeng, Zhi-Lei& Xiaopeng, Yang…[et al.]. 2020. Curcumin-Activated Mesenchymal Stem Cells Derived from Human Umbilical Cord and Their Effects on MPTP-Mouse Model of Parkinson’s Disease: A New Biological Therapy for Parkinson’s Disease. Stem Cells International،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1207743
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yunliang…[et al.]. Curcumin-Activated Mesenchymal Stem Cells Derived from Human Umbilical Cord and Their Effects on MPTP-Mouse Model of Parkinson’s Disease: A New Biological Therapy for Parkinson’s Disease. Stem Cells International No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1207743
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yunliang& Liu, Xin-Shan& Wang, Shan-Shan& Xue, Peng& Zeng, Zhi-Lei& Xiaopeng, Yang…[et al.]. Curcumin-Activated Mesenchymal Stem Cells Derived from Human Umbilical Cord and Their Effects on MPTP-Mouse Model of Parkinson’s Disease: A New Biological Therapy for Parkinson’s Disease. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1207743
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207743
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر