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Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution
المؤلفون المشاركون
DeLaney, Thomas F.
Schwab, Joseph H.
Nielsen, Gunnlaugur Petur
Choy, Edwin
Cote, Gregory M.
Miao, Ruoyu
Raskin, Kevin A.
Deshpande, Vikram
Chebib, Ivan
Hornicek, Francis J.
Chen, Yen-Lin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Dedifferentiated chondrosarcomas (DDCSs) are highly malignant tumors with a dismal prognosis and present a significant challenge in clinical management.
Methods.
In an IRB approved retrospective protocol, we identified 72 patients with DDCS treated at our institution between 1993 and 2017 and reviewed clinicopathological characteristics, treatment modalities, and outcomes to analyze prognostic factors.
Results.
Femur (44.4%), pelvis (22.2%), and humerus (12.5%) were most commonly involved sites.
Twenty-three patients (31.9%) presented with distant metastasis, and 3 (4.2%) of them also had regional lymph node involvement.
The median overall survival (OS) was 13.9 months.
On multivariate analysis, pathological fracture, larger tumor size, lymph node involvement, metastasis at diagnosis, extraosseous extension, and undifferentiated pleomorphic sarcoma component correlated with worse OS, whereas surgical resection and chemotherapy were associated with improved OS.
For progression-free survival (PFS), pathological fracture and metastasis at diagnosis showed increased risk, while chemotherapy was associated with decreased risk.
Among patients who received chemotherapy, doxorubicin and cisplatin were significantly associated with improved PFS but not OS.
Among patients without metastasis at diagnosis, 17 (34.7%) developed local recurrence.
Thirty-one (63.3%) developed distant metastases at a median interval of 18.1 months.
On multivariate analysis, R1/R2 resection was related with local recurrence, while macroscopic dedifferentiated component was associated with distant metastasis.
Conclusions.
The prognosis of DDCS is poor.
Complete resection remains a significant prognostic factor for local control.
Chemotherapy with doxorubicin and cisplatin seems to have better PFS.
More prognostic, multicenter trials are warranted to further explore the effectiveness of chemotherapy in selected DDCS patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miao, Ruoyu& Choy, Edwin& Raskin, Kevin A.& Schwab, Joseph H.& Nielsen, Gunnlaugur Petur& Deshpande, Vikram…[et al.]. 2019. Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution. Complexity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1207749
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miao, Ruoyu…[et al.]. Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution. Complexity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1207749
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miao, Ruoyu& Choy, Edwin& Raskin, Kevin A.& Schwab, Joseph H.& Nielsen, Gunnlaugur Petur& Deshpande, Vikram…[et al.]. Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution. Complexity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1207749
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207749
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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