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Combined Transplantation of Mesenchymal Stem Cells and Endothelial Colony-Forming Cells Accelerates Refractory Diabetic Foot Ulcer Healing
المؤلفون المشاركون
Luo, Yufang
Xiao, Qian
Yang, Wenjun
Guo, Zi
Mo, Zhaohui
Chen, Ke
Zhao, Liling
Wan, Xinxing
Zeng, Pingyu
He, Honghui
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-09
دولة النشر
مصر
عدد الصفحات
13
الملخص EN
Background.
This study is aimed at investigating the effect of combined transplantation of umbilical cord mesenchymal stem cells (UCMSCs) and umbilical cord blood-derived endothelial colony-forming cells (ECFCs) on diabetic foot ulcer healing and at providing a novel therapy for chronic diabetic foot ulcer.
Methods.
We reported the treatment of refractory diabetic foot ulcers in twelve patients.
Among them, five patients had two or more wounds; thus, one wound in the same patient was treated with cell injection, and other wounds were regarded as self-controls.
The remaining seven patients had only one wound; therefore, the difference between the area of wound before and after treatment was estimated.
The UCMSCs and ECFCs were injected into the wound along with topically applied hyaluronic acid (HA).
Results.
In this report, we compared the healing rate of multiple separate wounds in the same foot of the same patient: one treated with cell injection combined with topically applied HA-based hydrogel and was later covered by the hydrocolloid dressings, while the self-control wounds were only treated with conventional therapy and covered by the hydrocolloid dressings.
The wound underwent cell injection showed accelerated healing in comparison to control wound within the first week after treatment.
In other diabetic patients with only one refractory wound, the healing rate after cell transplantation was significantly faster than that before injection.
Two large wounds healed without needing skin grafts after combination therapy of cell injection and HA.
After four weeks of combination treatment, wound closure was reached in six patients, and the wounds of the other six patients were significantly reduced in size.
Conclusions.
Our study suggests that the combination of UCMSCs, ECFCs, and HA can safely synergize the accelerated healing of refractory diabetic foot ulcers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Liling& Guo, Zi& Chen, Ke& Yang, Wenjun& Wan, Xinxing& Zeng, Pingyu…[et al.]. 2020. Combined Transplantation of Mesenchymal Stem Cells and Endothelial Colony-Forming Cells Accelerates Refractory Diabetic Foot Ulcer Healing. Stem Cells International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1208013
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Liling…[et al.]. Combined Transplantation of Mesenchymal Stem Cells and Endothelial Colony-Forming Cells Accelerates Refractory Diabetic Foot Ulcer Healing. Stem Cells International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1208013
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Liling& Guo, Zi& Chen, Ke& Yang, Wenjun& Wan, Xinxing& Zeng, Pingyu…[et al.]. Combined Transplantation of Mesenchymal Stem Cells and Endothelial Colony-Forming Cells Accelerates Refractory Diabetic Foot Ulcer Healing. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1208013
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208013
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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