Antioxidant and Nephroprotective Effects of Okra Pods Extract (Abelmoschus esculentus L.) against Lead Acetate-Induced Toxicity in Mice
المؤلفون المشاركون
Wahyuningsih, Sri Puji Astuti
Savira, Nadyatul Ilma Indah
Anggraini, Devinta Wahyu
Winarni, Dwi
Suhargo, Listijani
Kusuma, Baskara Wiku Adi
Nindyasari, Faradita
Setianingsih, Nur
Mwendolwa, Adamu Ayubu
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In this study, we determine the curative effects of okra pods (Abelmoschus esculentus L.) extract against lead acetate toxicity in mice kidney.
n-Hexane, ethyl acetate, and methanol solvent were used for extracting okra pods.
The role of the extract as an antioxidant was tested by DPPH and FRAP methods.
The methanol extract was used for experiments in animals.
A total of 30 male BALB/c mice were randomly divided into six equal groups: normal control, negative control (lead-induced), and treatment groups (lead-induced for 28 days and administration of methanol extract at doses of 50, 100, 200, and 400 mg/kg BW for the 28 days).
The following were analyzed in all groups: activity of the antioxidant enzymes, namely, superoxide dismutase (SOD) and catalase (CAT); oxidant level, namely, malondialdehyde (MDA) and nitric oxide (NO); and markers of kidney injury, namely, blood urea nitrogen (BUN) and creatinine (Cre).
Kidney histopathology was also evaluated.
This study showed that the methanol extract showed the highest antioxidant activity (IC50 is 35.21 µg/mL, and FRAP is 57.58 µM Fe2+/g).
The CAT and SOD activities increased significantly in okra-treated groups (P<0.05).
The okra administration groups experienced a significant decrease in MDA, NO, BUN, and Cre levels (P<0.05).
Thickness of the epithelial proximal tubule, diameter of the proximal tubule, and percentage of necrotic cells in proximal tubule decreased, but the diameter ratio of glomerular Bowman’s capsule in mice treated with okra was optimally improved and repaired like normal control (P<0.05).
The results of this study reveal that methanol extract has a very strong antioxidant effect and can reduce the influence of toxicity induced by lead acetate in mice kidney.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wahyuningsih, Sri Puji Astuti& Savira, Nadyatul Ilma Indah& Anggraini, Devinta Wahyu& Winarni, Dwi& Suhargo, Listijani& Kusuma, Baskara Wiku Adi…[et al.]. 2020. Antioxidant and Nephroprotective Effects of Okra Pods Extract (Abelmoschus esculentus L.) against Lead Acetate-Induced Toxicity in Mice. Scientifica،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1208181
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wahyuningsih, Sri Puji Astuti…[et al.]. Antioxidant and Nephroprotective Effects of Okra Pods Extract (Abelmoschus esculentus L.) against Lead Acetate-Induced Toxicity in Mice. Scientifica No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1208181
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wahyuningsih, Sri Puji Astuti& Savira, Nadyatul Ilma Indah& Anggraini, Devinta Wahyu& Winarni, Dwi& Suhargo, Listijani& Kusuma, Baskara Wiku Adi…[et al.]. Antioxidant and Nephroprotective Effects of Okra Pods Extract (Abelmoschus esculentus L.) against Lead Acetate-Induced Toxicity in Mice. Scientifica. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1208181
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208181
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر