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Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment
المؤلفون المشاركون
Kanchanaphum, Panan
Dechkhajorn, Wilanee
Maneerat, Yaowapa
Prasongsukarn, Kriengchai
Kumsiri, Ratchanok
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The role of interleukin-8 (IL-8), a pivotal chemokine in atherogenesis and coronary heart disease (CHD) development, is diverse and remains unclear.
This cross-sectional study investigates the association of the IL-8 expression in hyperlipidemia (H) and CHD patients who have been treated with statin cholesterol-lowering drugs while undergoing coronary artery bypass grafting treatment.
Fifty-five Thai volunteers including 13 normal (N), 24 H, and 18 CHD patients were enrolled for the investigation.
All the CHD patients had been treated continuously with statin cholesterol-lowering medications since the disease was diagnosed and were undergoing coronary bypass grafting approximately one month later.
Therefore, the CHD group was representative of a pathogenesis improvement in CHD.
The IL8 mRNA expression was determined by real-time quantitative PCR in the peripheral blood mononuclear cells from heparinized blood.
The plasma IL-8 levels were assessed by enzyme-linked immunosorbent assay.
The result shows that the IL8 mRNA expression in the H group tended to increase; however, in the CHD group, there was a significant decrease (p=0.0111) compared to the N group.
The IL8 mRNA expression and the plasma levels in the CHD group were significantly lower than those in the H group (p<0.05).
A significant negative correlation between the IL8 mRNA (r = −0.499) or plasma IL-8 (r = −0.3875) expression and CHD progression was observed (p<0.05).
In conclusion, the transcriptomic and the phenotypic IL-8 expression decreased significantly in the Thai CHD patients who had continuously received statin-group medications compared to the H and N group participants.
Therefore, IL-8 should serve as a feasible marker and could be used to evaluate the therapeutic effects of statins and illustrate the pathology of CHD treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dechkhajorn, Wilanee& Maneerat, Yaowapa& Prasongsukarn, Kriengchai& Kanchanaphum, Panan& Kumsiri, Ratchanok. 2020. Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment. Scientifica،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1208209
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dechkhajorn, Wilanee…[et al.]. Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment. Scientifica No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1208209
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dechkhajorn, Wilanee& Maneerat, Yaowapa& Prasongsukarn, Kriengchai& Kanchanaphum, Panan& Kumsiri, Ratchanok. Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment. Scientifica. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1208209
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208209
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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