Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment
المؤلفون المشاركون
Kanchanaphum, Panan
Dechkhajorn, Wilanee
Maneerat, Yaowapa
Prasongsukarn, Kriengchai
Kumsiri, Ratchanok
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The role of interleukin-8 (IL-8), a pivotal chemokine in atherogenesis and coronary heart disease (CHD) development, is diverse and remains unclear.
This cross-sectional study investigates the association of the IL-8 expression in hyperlipidemia (H) and CHD patients who have been treated with statin cholesterol-lowering drugs while undergoing coronary artery bypass grafting treatment.
Fifty-five Thai volunteers including 13 normal (N), 24 H, and 18 CHD patients were enrolled for the investigation.
All the CHD patients had been treated continuously with statin cholesterol-lowering medications since the disease was diagnosed and were undergoing coronary bypass grafting approximately one month later.
Therefore, the CHD group was representative of a pathogenesis improvement in CHD.
The IL8 mRNA expression was determined by real-time quantitative PCR in the peripheral blood mononuclear cells from heparinized blood.
The plasma IL-8 levels were assessed by enzyme-linked immunosorbent assay.
The result shows that the IL8 mRNA expression in the H group tended to increase; however, in the CHD group, there was a significant decrease (p=0.0111) compared to the N group.
The IL8 mRNA expression and the plasma levels in the CHD group were significantly lower than those in the H group (p<0.05).
A significant negative correlation between the IL8 mRNA (r = −0.499) or plasma IL-8 (r = −0.3875) expression and CHD progression was observed (p<0.05).
In conclusion, the transcriptomic and the phenotypic IL-8 expression decreased significantly in the Thai CHD patients who had continuously received statin-group medications compared to the H and N group participants.
Therefore, IL-8 should serve as a feasible marker and could be used to evaluate the therapeutic effects of statins and illustrate the pathology of CHD treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dechkhajorn, Wilanee& Maneerat, Yaowapa& Prasongsukarn, Kriengchai& Kanchanaphum, Panan& Kumsiri, Ratchanok. 2020. Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment. Scientifica،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1208209
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dechkhajorn, Wilanee…[et al.]. Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment. Scientifica No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1208209
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dechkhajorn, Wilanee& Maneerat, Yaowapa& Prasongsukarn, Kriengchai& Kanchanaphum, Panan& Kumsiri, Ratchanok. Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment. Scientifica. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1208209
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208209
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر