Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling
المؤلفون المشاركون
Wang, Xiao
Jiao, Ya
Pan, Yi
Zhang, Longxiao
Gong, Hongmin
Qi, Yongjun
Wang, Maoying
Gong, Huiping
Shao, Mingju
Wang, Xinglei
Jiang, Duyin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-10
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Fetal dermal mesenchymal stem cells (FDMSCs), isolated from fetal skin, are serving as a novel MSC candidate with great potential in regenerative medicine.
More recently, the paracrine actions, especially MSC-derived exosomes, are being focused on the vital role in MSC-based cellular therapy.
This study was to evaluate the therapeutic potential of exosomes secreted by FDMSCs in normal wound healing.
First, the in vivo study indicated that FDMSC exosomes could accelerate wound closure in a mouse full-thickness skin wound model.
Then, we investigated the role of FDMSC-derived exosomes on adult dermal fibroblast (ADFs).
The results demonstrated that FDMSC exosomes could induce the proliferation, migration, and secretion of ADFs.
We discovered that after treatment of exosomes, the Notch signaling pathway was activated.
Then, we found that in FDMSC exosomes, the ligands of the Notch pathway were undetectable expect for Jagged 1, and the results of Jagged 1 mimic by peptide and knockdown by siRNA suggested that Jagged 1 may lead the activation of the Notch signal in ADFs.
Collectively, our findings indicated that the FDMSC exosomes may promote wound healing by activating the ADF cell motility and secretion ability via the Notch signaling pathway, providing new aspects for the therapeutic strategy of FDMSC-derived exosomes for the treatment of skin wounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xiao& Jiao, Ya& Pan, Yi& Zhang, Longxiao& Gong, Hongmin& Qi, Yongjun…[et al.]. 2019. Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling. Stem Cells International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1208446
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xiao…[et al.]. Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling. Stem Cells International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1208446
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xiao& Jiao, Ya& Pan, Yi& Zhang, Longxiao& Gong, Hongmin& Qi, Yongjun…[et al.]. Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1208446
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208446
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر