Impact of dual time point fdg pet imaging in the assessment of solitary pulmonary nodules
المؤلفون المشاركون
al-Khawlidah, Khalid
Alfi, Abbas
Khurays, Smir
المصدر
Journal of the Royal Medical Services
العدد
المجلد 15، العدد 2 (31 أغسطس/آب 2008)، ص ص. 6-14، 9ص.
الناشر
الخدمات الطبية الملكية الأردنية
تاريخ النشر
2008-08-31
دولة النشر
الأردن
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective: The aim of this study was to assess the diagnostic potential of 18F-FDG Positron Emission Tomography imaging in the evaluation of patients with solitary pulmonary nodules, by comparing the diagnostic criteria in single time point imaging method to two different diagnostic criteria in dual-time-point imaging.
Methods: This retrospective study was conducted in the Hospital of the University of Pennsylvania, and data was collected and analyzed in the period from September 2005 to March 2006, from the pooled hospital studies for the last eight years.
Two hundred sixty five patients were included (161 men, 104 women, age range: 41–92 years).
All had solitary pulmonary nodules on computed tomography, and the diagnosis was confirmed by biopsy or by follow up computed tomography.
All 265 patients underwent whole body FDG PET scan, and 255 of them had PET scan two time points.
The maximum standardized uptake values of nodules were calculated for both time points.
On single time point imaging we set the maximum standardized uptake value of 2.5 as a cutoff criterion for malignancy.
On dual time point imaging, first criterion of malignancy was set as any increase in the maximum SUV from the first to second time point.
The second criterion was set as either no change or increase in the maximum standardized uptake value between the two time points.
Sensitivity, specificity and accuracy were calculated for the three methods by using the biopsy results and clinical follow up as gold standard.
Results: Biopsy and follow-up revealed 72 patients with malignant lung nodules, whereas 193 patients had benign nodules.
Single time point imaging with a threshold maximum standardized uptake value of 2.5 had a sensitivity, specificity and accuracy of 63%, 92% and 85% respectively.
On dual-time-point imaging, for the initial criterion for malignancy, the sensitivity, specificity and accuracy were 81%, 95% and 91% respectively.
On dual time point imaging, for the second criterion for malignancy, the sensitivity, specificity and accuracy were 92%, 93%, and 92% respectively.
Conclusion: Dual-time-point FDG PET imaging using both criteria has higher sensitivity, specificity and accuracy compared to single time imaging.
Dual-time-point FDG PET imaging should be included in the clinical workup of patients with pulmonary nodule.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Khawlidah, Khalid& Khurays, Smir& Alfi, Abbas. 2008. Impact of dual time point fdg pet imaging in the assessment of solitary pulmonary nodules. Journal of the Royal Medical Services،Vol. 15, no. 2, pp.6-14.
https://search.emarefa.net/detail/BIM-120880
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Khawlidah, Khalid…[et al.]. Impact of dual time point fdg pet imaging in the assessment of solitary pulmonary nodules. Journal of the Royal Medical Services Vol. 15, no. 2 (Aug. 2008), pp.6-14.
https://search.emarefa.net/detail/BIM-120880
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Khawlidah, Khalid& Khurays, Smir& Alfi, Abbas. Impact of dual time point fdg pet imaging in the assessment of solitary pulmonary nodules. Journal of the Royal Medical Services. 2008. Vol. 15, no. 2, pp.6-14.
https://search.emarefa.net/detail/BIM-120880
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 13-14
رقم السجل
BIM-120880
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر