Intra-Bone Marrow Administration of Mesenchymal StemStromal Cells Is a Promising Approach for Treating Osteoporosis
المؤلفون المشاركون
Agata, Hideki
Sumita, Yoshinori
Hidaka, Tatsuro
Iwatake, Mayumi
Kagami, Hideaki
Asahina, Izumi
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-12
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases.
However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress.
In this study, we compared the safety and efficacy of intra-bone marrow and intravenous administration of MSCs for the treatment of ovariectomy- (OVX-) induced osteoporosis.
Cells capable of forming bone were isolated from the murine compact bones and expanded in culture.
Relatively pure MSCs possessing increased potential for cell proliferation, osteogenic differentiation, and inhibition of osteoclastogenesis were obtained by magnetic-activated cell sorting with the anti-Sca-1 antibody.
Sca-1-sorted MSCs were administered to OVX mice, which were sacrificed 1 month later.
We observed that 22% of the mice died after intravenous administration, whereas none of the mice died after intra-bone marrow administration.
With respect to efficacy, intravenous administration improved bone mineral density (BMD) by increasing bone mineral content without affecting bone thickness, whereas intra-bone marrow administration improved BMD by increasing both bone mineral content and bone thickness.
These results indicate that intra-bone marrow administration of pure MSCs is a safer and more effective approach for treating osteoporosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Agata, Hideki& Sumita, Yoshinori& Hidaka, Tatsuro& Iwatake, Mayumi& Kagami, Hideaki& Asahina, Izumi. 2019. Intra-Bone Marrow Administration of Mesenchymal StemStromal Cells Is a Promising Approach for Treating Osteoporosis. Stem Cells International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1208809
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Agata, Hideki…[et al.]. Intra-Bone Marrow Administration of Mesenchymal StemStromal Cells Is a Promising Approach for Treating Osteoporosis. Stem Cells International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1208809
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Agata, Hideki& Sumita, Yoshinori& Hidaka, Tatsuro& Iwatake, Mayumi& Kagami, Hideaki& Asahina, Izumi. Intra-Bone Marrow Administration of Mesenchymal StemStromal Cells Is a Promising Approach for Treating Osteoporosis. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1208809
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208809
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر