PTPN21 Overexpression Promotes Osteogenic and Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells but Inhibits the Immunosuppressive Function
المؤلفون المشاركون
Wang, Binsheng
Wang, Huafang
Ye, Xiaohang
Xiao, Haowen
Zhu, Ni
Wei, Cong
Sun, Xiang
Wang, Limengmeng
Yu, Xiaohong
Lai, Xiaoyu
Fu, Shan
Huang, He
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-21
دولة النشر
مصر
عدد الصفحات
19
الملخص EN
Protein tyrosine phosphatases (PTPs) act as key regulators in various cellular processes such as proliferation, differentiation, and migration.
Our previous research demonstrated that non-receptor-typed PTP21 (PTPN21), a member of the PTP family, played a critical role in the proliferation, cell cycle, and chemosensitivity of acute lymphoblastic leukemia cells.
However, the role of PTPN21 in the bone marrow microenvironment has not yet been elucidated.
In the study, we explored the effects of PTPN21 on human bone marrow-derived mesenchymal stem cells (BM-MSCs) via lentiviral-mediated overexpression and knock-down of PTPN21 in vitro.
Overexpressing PTPN21 in BM-MSCs inhibited the proliferation through arresting cell cycle at the G0 phase but rendered them a higher osteogenic and adipogenic differentiation potential.
In addition, overexpressing PTPN21 in BM-MSCs increased their senescence levels through upregulation of P21 and P53 and dramatically changed the levels of crosstalk with their typical target cells including immunocytes, tumor cells, and vascular endothelial cells.
BM-MSCs overexpressing PTPN21 had an impaired immunosuppressive function and an increased capacity of recruiting tumor cells and vascular endothelial cells in a chemotaxis transwell coculture system.
Collectively, our data suggested that PTPN21 acted as a pleiotropic factor in modulating the function of human BM-MSCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Huafang& Ye, Xiaohang& Xiao, Haowen& Zhu, Ni& Wei, Cong& Sun, Xiang…[et al.]. 2019. PTPN21 Overexpression Promotes Osteogenic and Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells but Inhibits the Immunosuppressive Function. Stem Cells International،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1208881
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Huafang…[et al.]. PTPN21 Overexpression Promotes Osteogenic and Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells but Inhibits the Immunosuppressive Function. Stem Cells International No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1208881
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Huafang& Ye, Xiaohang& Xiao, Haowen& Zhu, Ni& Wei, Cong& Sun, Xiang…[et al.]. PTPN21 Overexpression Promotes Osteogenic and Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells but Inhibits the Immunosuppressive Function. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1208881
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208881
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر