Daytime QT by Routine 12-Lead ECG Is Prolonged in Patients with Severe Obstructive Sleep Apnea
المؤلفون المشاركون
Mazimba, Sula
Kwon, Younghoon
Walker, McCall
Blackwell, Jacob N.
Stafford, Patrick
Patel, Paras
Mehta, Nishaki
Cho, Yeilim
Mangrum, Michael
Nazarian, Saman
Bilchick, Kenneth
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Obstructive sleep apnea (OSA) has been linked to sudden cardiac death (SCD).
Prolonged QT is a recognized electrocardiographic (ECG) marker of abnormal ventricular repolarization linked to increased risk of SCD.
We hypothesized that individuals with OSA have more pronounced abnormality in daytime QT interval.
Methods.
We reviewed consecutive patients who underwent clinically indicated polysomnography with 12-lead ECG within 1 year at a single center.
Heart rate-corrected QT interval (QTc) was compared by OSA severity class (normal/mild: apnea‐hypopnea index AHI<15/hr (n=72); moderate: 15-30 (n=72); severe: >30 (n=105)) adjusting for body mass index, age, sex, hypertension, and heart failure.
Further evaluation was performed by dividing patients into severe (AHI>30) and nonsevere (<30) OSA.
Logistic analysis was used to determine association of OSA severity and abnormal QTc (>450/>470 ms for men/women, respectively).
Results.
A total of 249 patients were included.
QTc was similar between the normal/mild and moderate groups, and the overall QTc trend increased across OSA (normal/mild: 435.6 ms; moderate: 431.36; severe: 444.4; p trend=0.03).
Abnormal QTc was found amongst 34% of male and 31% of female patients.
Patients with severe OSA had longer QTc compared with normal/mild OSA (mean difference (95% CI): 10.0 ms (0.5, 19.0), p=0.04).
When stratified dichotomously (as opposed to three groups), patients with severe OSA again had longer QTc (vs.
nonsevere OSA) (444.4 ms vs.
433.48 ms, p=0.004).
Severe OSA was also associated with abnormal QTc (OR (95% CI): 2.68 (1.34, 5.48), p=0.006).
Conclusions.
In a sleep clinic cohort, severe OSA was associated with higher QTc and clinically defined abnormal QTc compared with nonsevere OSA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Walker, McCall& Blackwell, Jacob N.& Stafford, Patrick& Patel, Paras& Mazimba, Sula& Mehta, Nishaki…[et al.]. 2020. Daytime QT by Routine 12-Lead ECG Is Prolonged in Patients with Severe Obstructive Sleep Apnea. Sleep Disorders،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1208927
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Walker, McCall…[et al.]. Daytime QT by Routine 12-Lead ECG Is Prolonged in Patients with Severe Obstructive Sleep Apnea. Sleep Disorders No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1208927
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Walker, McCall& Blackwell, Jacob N.& Stafford, Patrick& Patel, Paras& Mazimba, Sula& Mehta, Nishaki…[et al.]. Daytime QT by Routine 12-Lead ECG Is Prolonged in Patients with Severe Obstructive Sleep Apnea. Sleep Disorders. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1208927
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208927
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر