Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome
المؤلفون المشاركون
Msaad, Sameh
Chaabouni, Akram
Marrakchi, Rim
Boudaya, Mariem
Kotti, Amina
Feki, Walid
Jamoussi, Kamel
Kammoun, Samy
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Systemic and airway inflammation has recently been linked to obstructive sleep apnea-hypopnea syndrome (OSAHS) and is considered to be a probable risk factor for OSAHS-induced cardiovascular damage.
High-sensitivity C-reactive protein (hs-CRP), as an inflammatory mediator, may be useful for the prediction of the risk of cardiovascular disease (CVD) and assessment of nocturnal continuous positive airway pressure (nCPAP) therapy effect in OSAHS patients.
Methods.
A prospective, controlled, cross-sectional study was conducted on 64 consecutive adult subjects with suspected sleep-disordered breathing (SDB).
Results.
OSAHS was confirmed in 43 patients (24 normotensive and 19 hypertensive patients) and ruled out in 21 normotensive subjects (controls).
The median plasma level of hs-CRP did not differ significantly between OSAHS patients and controls.
It showed an unmarked rise with the severity of OSAHS (p=0.20) and was not correlated with AHI (p=0.067; r=0.28).
After adjusting for cervical perimeter (CP), waist-to-hip ratio (WHR), and blood sugar level, hs-CRP level of 1 mg/dL or greater was significantly more often observed in OSAHS patients compared with controls (p=0.032; OR=5.60) and was also significantly associated with AHI (p=0.021).
A significant decrease in the median plasma hs-CRP level was observed in CPAP compliant patients (p=0.006).
Of those, only normotensive patients showed a significant decrease in plasma hs-CRP level.
In hypertensive ones, however, the hs-CRP level dropped but not significantly.
Using a linear regression model, the change in hs-CRP level (Δhs-CRP) following a 6-month-nCPAP therapy was found to positively correlate with the baseline hs-CRP level for both hypertensive (p=0.02; r=0.68), and even more normotensive OSAHS patients (p<0.0001; r=0.89).
Conclusion.
nCPAP therapy may have a cardiovascular protective effect in OSAHS patients.
hs-CRP level would be useful as a valuable predictor of success in OSAHS treatment monitoring.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Msaad, Sameh& Chaabouni, Akram& Marrakchi, Rim& Boudaya, Mariem& Kotti, Amina& Feki, Walid…[et al.]. 2020. Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome. Sleep Disorders،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1208951
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Msaad, Sameh…[et al.]. Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome. Sleep Disorders No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1208951
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Msaad, Sameh& Chaabouni, Akram& Marrakchi, Rim& Boudaya, Mariem& Kotti, Amina& Feki, Walid…[et al.]. Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome. Sleep Disorders. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1208951
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208951
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر