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Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome
المؤلفون المشاركون
Msaad, Sameh
Chaabouni, Akram
Marrakchi, Rim
Boudaya, Mariem
Kotti, Amina
Feki, Walid
Jamoussi, Kamel
Kammoun, Samy
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Systemic and airway inflammation has recently been linked to obstructive sleep apnea-hypopnea syndrome (OSAHS) and is considered to be a probable risk factor for OSAHS-induced cardiovascular damage.
High-sensitivity C-reactive protein (hs-CRP), as an inflammatory mediator, may be useful for the prediction of the risk of cardiovascular disease (CVD) and assessment of nocturnal continuous positive airway pressure (nCPAP) therapy effect in OSAHS patients.
Methods.
A prospective, controlled, cross-sectional study was conducted on 64 consecutive adult subjects with suspected sleep-disordered breathing (SDB).
Results.
OSAHS was confirmed in 43 patients (24 normotensive and 19 hypertensive patients) and ruled out in 21 normotensive subjects (controls).
The median plasma level of hs-CRP did not differ significantly between OSAHS patients and controls.
It showed an unmarked rise with the severity of OSAHS (p=0.20) and was not correlated with AHI (p=0.067; r=0.28).
After adjusting for cervical perimeter (CP), waist-to-hip ratio (WHR), and blood sugar level, hs-CRP level of 1 mg/dL or greater was significantly more often observed in OSAHS patients compared with controls (p=0.032; OR=5.60) and was also significantly associated with AHI (p=0.021).
A significant decrease in the median plasma hs-CRP level was observed in CPAP compliant patients (p=0.006).
Of those, only normotensive patients showed a significant decrease in plasma hs-CRP level.
In hypertensive ones, however, the hs-CRP level dropped but not significantly.
Using a linear regression model, the change in hs-CRP level (Δhs-CRP) following a 6-month-nCPAP therapy was found to positively correlate with the baseline hs-CRP level for both hypertensive (p=0.02; r=0.68), and even more normotensive OSAHS patients (p<0.0001; r=0.89).
Conclusion.
nCPAP therapy may have a cardiovascular protective effect in OSAHS patients.
hs-CRP level would be useful as a valuable predictor of success in OSAHS treatment monitoring.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Msaad, Sameh& Chaabouni, Akram& Marrakchi, Rim& Boudaya, Mariem& Kotti, Amina& Feki, Walid…[et al.]. 2020. Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome. Sleep Disorders،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1208951
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Msaad, Sameh…[et al.]. Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome. Sleep Disorders No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1208951
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Msaad, Sameh& Chaabouni, Akram& Marrakchi, Rim& Boudaya, Mariem& Kotti, Amina& Feki, Walid…[et al.]. Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome. Sleep Disorders. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1208951
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208951
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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