Levels of Intestinal Inflammation and Fibrosis in Resection Specimens after Preoperative Anti-Tumor Necrosis Factor Alpha Treatment in Patients with Crohn’s Disease: A Comparative Pilot Study
المؤلفون المشاركون
Qvist, Niels
Torle, J.
Dabir, P. D.
Korsgaard, U.
Christiansen, J.
El-Hussuna, A.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Strictures are a common complication in Crohn’s disease (CD), found in more than 50% of patients.
They are characterized by the excessive deposition of extracellular proteins in the tissue as a result of the chronic inflammatory process.
The effect of anti-tumor necrosis factor alpha (TNF-α) therapy on the development of fibrosis is not yet fully understood.
Aim.
To investigate whether the degree of intestinal inflammation and fibrosis is correlated with preoperative anti-TNF-α therapy in patients with CD who are undergoing bowel resection.
Methods.
This unblinded, prospective, single tertiary center, pilot cohort study included all adult patients with CD who underwent elective, laparoscopic, or open intestinal resection.
Preoperative investigations included measurement of blood TNF-α concentration, specific antidrug antibodies, and the concentration of selected inflammatory cytokines.
Three pathologists independently examined the specimens and assessed the degree of inflammation and fibrosis.
Results.
Histopathological specimens from 10 patients with CD who underwent ileocecal or ileocolic resections were retrieved.
Four of those patients were on anti-TNF-α treatment prior to surgery.
The last dose of the anti-TNF-α agent was administered 1–9 weeks prior to bowel resection.
Patients on anti-TNF-α treatment had a higher fibrosis score than controls (p=0.01).
Anti-TNF-α treatment was not associated with an increase in CD68- or CD163-positive macrophages.
There was no significant relationship between the time from the final preoperative anti-TNF-α dose to surgery and the fibrosis score.
No significant association was found between the concentration of major inflammatory cytokines, including TNF-α, and the fibrosis score or degree of inflammation.
Conclusions.
Patients who underwent preoperative anti-TNF-α treatment had a higher fibrosis score than controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Torle, J.& Dabir, P. D.& Korsgaard, U.& Christiansen, J.& Qvist, Niels& El-Hussuna, A.. 2020. Levels of Intestinal Inflammation and Fibrosis in Resection Specimens after Preoperative Anti-Tumor Necrosis Factor Alpha Treatment in Patients with Crohn’s Disease: A Comparative Pilot Study. Surgery Research and Practice،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1209381
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Torle, J.…[et al.]. Levels of Intestinal Inflammation and Fibrosis in Resection Specimens after Preoperative Anti-Tumor Necrosis Factor Alpha Treatment in Patients with Crohn’s Disease: A Comparative Pilot Study. Surgery Research and Practice No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1209381
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Torle, J.& Dabir, P. D.& Korsgaard, U.& Christiansen, J.& Qvist, Niels& El-Hussuna, A.. Levels of Intestinal Inflammation and Fibrosis in Resection Specimens after Preoperative Anti-Tumor Necrosis Factor Alpha Treatment in Patients with Crohn’s Disease: A Comparative Pilot Study. Surgery Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1209381
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209381
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر