Transcranial Doppler for Early Prediction of Cognitive Impairment after Aneurysmal Subarachnoid Hemorrhage and the Associated Clinical Biomarkers
المؤلفون المشاركون
Esmael, Ahmed
Belal, Tamer
Eltoukhy, Khaled
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background and Aim.
Cognitive impairment after aneurysmal subarachnoid hemorrhage (aSAH) stays under investigation.
This study is aimed at predicting the cognitive impairment by transcranial Doppler (TCD) and detecting the associated clinical biomarkers of impaired cognition after aSAH after 3 months from the onset.
Methods.
Prospective study included 40 cases with acute aSAH.
Initial evaluation by Glasgow Coma Scale (GCS) and the severity of aSAH was detected by both the clinical Hunt and Hess and radiological Fisher’s grading scales.
TCD was done for all patients five times within 10 days measuring the mean flow velocities (MFVs) of cerebral arteries.
At the 3-month follow-up, patients were classified into two groups according to Montreal Cognitive Assessment (MoCA) scale: the first group was 31 cases (77.5%) with intact cognitive functions and the other group was 9 cases (22.5%) with impaired cognition.
Results.
Patients with impaired cognitive functions showed significantly lower mean GCS (p=0.03), significantly higher mean Hunt and Hess scale grades (p=0.04), significantly higher mean diabetes mellitus (DM) (p=0.03), significantly higher mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) (p=0.02 and p=0.005, respectively), and significantly higher MFVs measured within the first 10 days.
The patients with cognitive impairment were accompanied by a higher incidence of hydrocephalus (p=0.01) and a higher incidence of delayed cerebral ischemia (DCI) (p<0.001).
Logistic regression analysis detected that MFV≥86 cm/s in the middle cerebral artery (MCA), MFV≥68 cm/s in the anterior cerebral artery (ACA), and MFV≥45 cm/s in the posterior cerebral artery (PCA) were significantly associated with increased risk of cognitive impairment.
Conclusion.
Cognitive impairment after the 3-month follow-up phase in aSAH patients was 22.5%.
Acute hydrocephalus and DCI are highly associated with poor cognitive function in aSAH.
Increased MFV is a strong predictor for poor cognitive function in aSAH.
This trial is registered with NCT04329208.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Esmael, Ahmed& Belal, Tamer& Eltoukhy, Khaled. 2020. Transcranial Doppler for Early Prediction of Cognitive Impairment after Aneurysmal Subarachnoid Hemorrhage and the Associated Clinical Biomarkers. Stroke Research and Treatment،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1209410
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Esmael, Ahmed…[et al.]. Transcranial Doppler for Early Prediction of Cognitive Impairment after Aneurysmal Subarachnoid Hemorrhage and the Associated Clinical Biomarkers. Stroke Research and Treatment No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1209410
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Esmael, Ahmed& Belal, Tamer& Eltoukhy, Khaled. Transcranial Doppler for Early Prediction of Cognitive Impairment after Aneurysmal Subarachnoid Hemorrhage and the Associated Clinical Biomarkers. Stroke Research and Treatment. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1209410
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209410
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر