Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System
المؤلفون المشاركون
Sidahmed, Heba
Cugno, Chiara
Guerrouahen, Bella S.
Al Sulaiti, Asma
Al Khulaifi, Moza
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-05
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Mesenchymal stromal cells (MSCs), formerly known as mesenchymal stem cells, are nonhematopoietic multipotent cells and are emerging worldwide as the most clinically used and promising source for allogeneic cell therapy.
MSCs, initially obtained from bone marrow, can be derived from several other tissues, such as adipose tissue, placenta, and umbilical cord.
Diversity in tissue sourcing and manufacturing procedures has significant effects on MSC products.
However, in 2006, a minimal set of standard criteria has been issued by the International Society of Cellular Therapy for defining derived MSCs.
These include adherence to plastic in conventional culture conditions, particular phenotype, and multilineage differentiation capacity in vitro.
Moreover, MSCs have trophic capabilities, a high in vitro self-renewal ability, and immunomodulatory characteristics.
Thus, immunosuppressive treatment with MSCs has been proposed as a potential therapeutic alternative for conditions in which the immune system cells influence outcomes, such as inflammatory and autoimmune diseases.
The precise mechanism by which MSCs affect functions of most immune effector cells is not completely understood but involves direct contact with immune cells, soluble mediators, and local microenvironmental factors.
Recently, it has been shown that their homeostatic resting state requires activation, which can be achieved in vitro with various cytokines, including interferon-γ.
In the present review, we focus on the suppressive effect that MSCs exert on the immune system and highlight the significance of in vitro preconditioning and its use in preclinical studies.
We discuss the clinical aspects of using MSCs as an immunomodulatory treatment.
Finally, we comment on the risk of interfering with the immune system in regard to cancer formation and development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guerrouahen, Bella S.& Sidahmed, Heba& Al Sulaiti, Asma& Al Khulaifi, Moza& Cugno, Chiara. 2019. Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System. Stem Cells International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1209499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guerrouahen, Bella S.…[et al.]. Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System. Stem Cells International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1209499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guerrouahen, Bella S.& Sidahmed, Heba& Al Sulaiti, Asma& Al Khulaifi, Moza& Cugno, Chiara. Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1209499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر