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An Investigation about Gene Modules Associated with hDPSC Differentiation for Adolescents
المؤلفون المشاركون
Qiu, Weiliang
Xu, Wenjing
Li, Jianqiang
Li, Juan
Yang, Ji-Jiang
Wang, Qing
Liu, Bo
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-04
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Dental pulp stem cells (DPSCs) have the property of self-renewal and multidirectional differentiation so that they have the potential for future regenerative therapy of various diseases.
The latest breakthrough in the biology of stem cells and the development of regenerative biology provides an effective strategy for regenerative therapy.
However, in the medium promoting differentiation during long-term passage, DPSCs would lose their differentiation capability.
Some efforts have been made to find genes influencing human DPSC (hDPSC) differentiation based on hDPSCs isolated from adults.
However, hDPSC differentiation is a very complex process, which involves multiple genes and multielement interactions.
The purpose of this study is to detect sets of correlated genes (i.e., gene modules) that are associated to hDPSC differentiation at the crown-completed stage of the third molars, by using weighted gene coexpression network analysis (WGCNA).
Based on the gene expression dataset GSE10444 from Gene Expression Omnibus (GEO), we identified two significant gene modules: yellow module (742 genes) and salmon module (9 genes).
The WEB-based Gene SeT AnaLysis Toolkit showed that the 742 genes in the yellow module were enriched in 59 KEGG pathways (including Wnt signaling pathway), while the 9 genes in the salmon module were enriched in one KEGG pathway (neurotrophin signaling pathway).
There were 660 (7) genes upregulated at P10 and 82 (2) genes downregulated at P10 in the yellow (salmon) module.
Our results provide new insights into the differentiation capability of hDPSCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Wenjing& Li, Jianqiang& Li, Juan& Yang, Ji-Jiang& Wang, Qing& Liu, Bo…[et al.]. 2019. An Investigation about Gene Modules Associated with hDPSC Differentiation for Adolescents. Stem Cells International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1209857
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Wenjing…[et al.]. An Investigation about Gene Modules Associated with hDPSC Differentiation for Adolescents. Stem Cells International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1209857
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Wenjing& Li, Jianqiang& Li, Juan& Yang, Ji-Jiang& Wang, Qing& Liu, Bo…[et al.]. An Investigation about Gene Modules Associated with hDPSC Differentiation for Adolescents. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1209857
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209857
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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