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Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence
المؤلفون المشاركون
Huang, Yi-Bo
Yang, Juan-Mei
Chi, Fang-Lu
Ren, Dong-Dong
Jia, Xian-Hao
Tong, Bu-Sheng
He, Zi-Yu
Ding, Chen-Ru
Wang, Jing
Han, Zhao
Gao, Na
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Defective acoustic transmission in the cochlea is closely related with various auditory and vestibular symptoms.
Among them, semicircular canal dehiscence (SCD) with a defective semicircular bone is typical.
Currently, the pathogenesis of SCD is usually explained by the third window hypothesis; however, this hypothesis fails to explain the variability in the symptoms and signs experienced by superior SCD (SSCD) patients.
We evaluated the mechanism of hearing loss in a guinea pig model of bony dehiscence with various sizes and locations along the superior semicircular canal.
Auditory brainstem responses (ABRs) and laser Doppler velocimetry were used to measure hearing loss and vibration changes before and after fenestration, as well as after restorative patching.
ABR thresholds at low frequencies (e.g., 1000 Hz) increased after fenestration and decreased back to the normal range after we repaired the defect.
Energy leakage from the surgically introduced third window was detected in the range of 300–1500 Hz, accompanied by increased vibration at the umbo, stapes head, and the dehiscence site, while decreased vibration was observed at the round window membrane in the same frequency range.
After the patching procedure, the deviant vibrations were recovered.
The degree of postfenestration energy leakage was proportional to the size of fenestration and the proximity of the fenestration site to the oval window.
These results suggest that the bony fenestration of the superior semicircular canal mimics the hearing loss pattern of patients with SSCD.
The decrease in perilymph wave impedance likely accounts for the auditory changes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tong, Bu-Sheng& He, Zi-Yu& Ding, Chen-Ru& Yang, Juan-Mei& Wang, Jing& Han, Zhao…[et al.]. 2018. Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence. Neural Plasticity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1209939
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tong, Bu-Sheng…[et al.]. Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence. Neural Plasticity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1209939
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tong, Bu-Sheng& He, Zi-Yu& Ding, Chen-Ru& Yang, Juan-Mei& Wang, Jing& Han, Zhao…[et al.]. Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1209939
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209939
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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