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Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain
المؤلفون المشاركون
Villela, Darine
Grinberg, Lea Tenenholz
Rosenberg, Carla
Suemoto, Claudia K.
Pasqualucci, Carlos Augusto
Leite, Renata
Pearson, Peter
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aging is a complex process strongly determined by genetics.
Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs).
CNVs represent a significant source of genetic variation in the human genome and have been implicated in several disorders and complex traits, representing a potential mechanism that contributes to neuronal diversity and the etiology of several neurological diseases and provides new insights into the normal, complex functions of the brain.
Nonetheless, the features of somatic CNV mosaicism in nondiseased elderly brains have not been investigated.
In the present study, we demonstrate a highly significant increase in the number of CNVs in nondiseased elderly brains compared to the blood.
In two neural tissues isolated from paired postmortem samples (same individuals), we found a significant increase in the frequency of deletions in both brain areas, namely, the frontal cortex and cerebellum.
Also, deletions were found to be significantly larger when present only in the cerebellum.
The sizes of the variants described here were in the 150–760 kb range, and importantly, nearly all of them were present in the Database of Genomic Variants (common variants).
Nearly all evidence of genome structural variation in human brains comes from studies detecting changes in single cells which were interpreted as derived from independent, isolated mutational events.
The observations based on array-CGH analysis indicate the existence of an extensive clonal mosaicism of CNVs within and between the human brains revealing a different type of variation that had not been previously characterized.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Villela, Darine& Suemoto, Claudia K.& Leite, Renata& Pasqualucci, Carlos Augusto& Grinberg, Lea Tenenholz& Pearson, Peter…[et al.]. 2018. Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain. Neural Plasticity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1209986
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Villela, Darine…[et al.]. Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain. Neural Plasticity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1209986
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Villela, Darine& Suemoto, Claudia K.& Leite, Renata& Pasqualucci, Carlos Augusto& Grinberg, Lea Tenenholz& Pearson, Peter…[et al.]. Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1209986
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209986
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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