Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington’s Disease
المؤلفون المشاركون
de Paula Nascimento-Castro, Cristine
Wink, Ana Claudia
da Fônseca, Victor Silva
Bianco, Claudia Daniele
Winkelmann-Duarte, Elisa C.
Rodrigues, Ana Lúcia S.
de Bem, Andreza Fabro
Brocardo, Patricia S.
Gil-Mohapel, Joana
Farina, Marcelo
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-14
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a trinucleotide expansion in the HD gene, resulting in an extended polyglutamine tract in the protein huntingtin.
HD is traditionally viewed as a movement disorder, but cognitive and neuropsychiatric symptoms also contribute to the clinical presentation.
Depression is one of the most common psychiatric disturbances in HD, present even before manifestation of motor symptoms.
Diagnosis and treatment of depression in HD-affected individuals are essential aspects of clinical management in this population, especially owing to the high risk of suicide.
This study investigated whether chronic administration of the antioxidant probucol improved motor and affective symptoms as well as hippocampal neurogenic function in the YAC128 transgenic mouse model of HD during the early- to mild-symptomatic stages of disease progression.
The motor performance and affective symptoms were monitored using well-validated behavioral tests in YAC128 mice and age-matched wild-type littermates at 2, 4, and 6 months of age, after 1, 3, or 5 months of treatment with probucol (30 mg/kg/day via water supplementation, starting on postnatal day 30).
Endogenous markers were used to assess the effect of probucol on cell proliferation (Ki-67 and proliferation cell nuclear antigen (PCNA)) and neuronal differentiation (doublecortin (DCX)) in the hippocampal dentate gyrus (DG).
Chronic treatment with probucol reduced the occurrence of depressive-like behaviors in early- and mild-symptomatic YAC128 mice.
Functional improvements were not accompanied by increased progenitor cell proliferation and neuronal differentiation.
Our findings provide evidence that administration of probucol may be of clinical benefit in the management of early- to mild-symptomatic HD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Paula Nascimento-Castro, Cristine& Wink, Ana Claudia& da Fônseca, Victor Silva& Bianco, Claudia Daniele& Winkelmann-Duarte, Elisa C.& Farina, Marcelo…[et al.]. 2018. Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington’s Disease. Neural Plasticity،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1210073
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Paula Nascimento-Castro, Cristine…[et al.]. Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington’s Disease. Neural Plasticity No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1210073
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Paula Nascimento-Castro, Cristine& Wink, Ana Claudia& da Fônseca, Victor Silva& Bianco, Claudia Daniele& Winkelmann-Duarte, Elisa C.& Farina, Marcelo…[et al.]. Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington’s Disease. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1210073
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210073
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر