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Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling
المؤلفون المشاركون
Spano, PierFranco
Mora, Cristina
Gennarelli, Massimo
Kunath, Tilo
Bono, Federica
Collo, Ginetta
Cavalleri, Laura
Fedele, Stefania
Invernizzi, Roberto William
Piovani, Giovanna
Millan, Mark J.
Merlo Pich, Emilio
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-04
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The antiparkinsonian ropinirole and pramipexole are D3 receptor- (D3R-) preferring dopaminergic (DA) agonists used as adjunctive therapeutics for the treatment resistant depression (TRD).
While the exact antidepressant mechanism of action remains uncertain, a role for D3R in the restoration of impaired neuroplasticity occurring in TRD has been proposed.
Since D3R agonists are highly expressed on DA neurons in humans, we studied the effect of ropinirole and pramipexole on structural plasticity using a translational model of human-inducible pluripotent stem cells (hiPSCs).
Two hiPSC clones from healthy donors were differentiated into midbrain DA neurons.
Ropinirole and pramipexole produced dose-dependent increases of dendritic arborization and soma size after 3 days of culture, effects antagonized by the selective D3R antagonists SB277011-A and S33084 and by the mTOR pathway kinase inhibitors LY294002 and rapamycin.
All treatments were also effective in attenuating the D3R-dependent increase of p70S6-kinase phosphorylation.
Immunoneutralisation of BDNF, inhibition of TrkB receptors, and blockade of MEK-ERK signaling likewise prevented ropinirole-induced structural plasticity, suggesting a critical interaction between BDNF and D3R signaling pathways.
The highly similar profiles of data acquired with DA neurons derived from two hiPSC clones underpin their reliability for characterization of pharmacological agents acting via dopaminergic mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Collo, Ginetta& Cavalleri, Laura& Bono, Federica& Mora, Cristina& Fedele, Stefania& Invernizzi, Roberto William…[et al.]. 2018. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plasticity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Collo, Ginetta…[et al.]. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plasticity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1210081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Collo, Ginetta& Cavalleri, Laura& Bono, Federica& Mora, Cristina& Fedele, Stefania& Invernizzi, Roberto William…[et al.]. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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