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Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late “P300-Like” Event-Related Potential in Rats
المؤلفون المشاركون
Ahnaou, A.
Drinkenburg, W. H.
Biermans, R.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-16
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Event-related potentials (ERPs) and oscillations (EROs) provide powerful tools for studying the brain’s synaptic function underlying information processing.
The P300 component of ERPs indexing attention and working memory shows abnormal amplitude and latency in neurological and psychiatric diseases that are sensitive to pharmacological agents.
In the active auditory oddball discriminant paradigm, behavior and auditory-evoked potentials (AEPs) were simultaneously recorded in awake rats to investigate whether P300-like potentials generated in rats responding to rare target oddball tones are sensitive to subcutaneous modulation of the cholinergic tone by donepezil (1 mg/kg) and scopolamine (0.64 mg/kg).
After operant training, rats consistently discriminate rare target auditory stimuli from frequent irrelevant nontarget auditory stimuli by a higher level of correct lever presses (i.e., accuracy) in target trials associated with a food reward.
Donepezil attenuated the disruptive effect of scopolamine on the level of accuracy and premature responses in target trials.
Larger P300-like peaks with early and late components were revealed in correct rare target stimuli trials as compared to frequent tones.
Donepezil enhanced the peak amplitude of the P300-like component to target stimuli and evoked slow theta and gamma oscillations, whereas scopolamine altered the amplitude of the P300-like component and EROs to target stimuli.
Pretreatment with donepezil attenuated effects of scopolamine on the peak amplitude of the P300-like component and on EROs.
This study provides evidence that AEP P300-like responses can be elicited by rats engaged in attentive and memory processing of target stimuli and outline the relevance of the cholinergic system in stimulus discrimination processing.
The findings highlight the sensitivity of this translational index for investigating brain circuits and/or novel pharmacological agents, which modulate cholinergic transmission associated with increased allocation of attentional resources.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahnaou, A.& Biermans, R.& Drinkenburg, W. H.. 2018. Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late “P300-Like” Event-Related Potential in Rats. Neural Plasticity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahnaou, A.…[et al.]. Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late “P300-Like” Event-Related Potential in Rats. Neural Plasticity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1210089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahnaou, A.& Biermans, R.& Drinkenburg, W. H.. Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late “P300-Like” Event-Related Potential in Rats. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210089
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