Danshen-Honghua Ameliorates Stress-Induced Menopausal Depression in Rats
المؤلفون المشاركون
Gu, Simeng
Li, Yang
Ma, Yao
Ge, Kemin
Nie, Ruifang
Wu, Erxi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-03
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
Previously, we have shown that Danshen-Honghua (DSHH) for cognitive deficits after ischemia induced impairments of the hippocampus.
Here, we investigate the effects of DSHH on stress-induced depression in menopausal rats.
Methods.
A rat model with menopausal depression was established with bilateral ovariectomies in female SD rats followed by chronic mild stress treatment for 21 days.
40 rats were randomly divided into the sham surgery group (sham surgery and no stress treatment), surgery group (surgery with no stress treatment), surgery/stress group (surgery and stress treatment), fluoxetine group (2.4 mg·kg−1, with surgery and stress treatment), and DSHH group (35 g·kg−1, with surgery and stress treatment).
The rats in the last two groups were treated with stresses together with intragastric drug administration for three weeks after the surgery.
Then open-field locomotor scores and sucrose intake were tested for behavior changes.
Also, the levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT), and cortisone were determined by high-performance liquid chromatography (HPLC).
Serum estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were determined by radioimmunoassay.
Results.
The results of open-field locomotor scores, sucrose intake in both the fluoxetine group and DSHH group, were significantly higher than those of the surgery/stress group (P<0.01).
Serum LH, FSH, and cortisone levels in both the DSHH group and fluoxetine group were significantly lower than those in the surgery/stress group (P<0.01).
Serum E2 levels in these groups were slightly increased in these medicine groups (P<0.01).
The monoamine levels in the DSHH group were much higher than those in the surgery/stress group (P<0.01).
Conclusion.
DSHH can ameliorate stress-induced depressed syndromes in the surgery/stressed rats via regulating LH and FSH levels as well as monoamine levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gu, Simeng& Ma, Yao& Ge, Kemin& Nie, Ruifang& Wu, Erxi& Li, Yang. 2018. Danshen-Honghua Ameliorates Stress-Induced Menopausal Depression in Rats. Neural Plasticity،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1210284
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gu, Simeng…[et al.]. Danshen-Honghua Ameliorates Stress-Induced Menopausal Depression in Rats. Neural Plasticity No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1210284
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gu, Simeng& Ma, Yao& Ge, Kemin& Nie, Ruifang& Wu, Erxi& Li, Yang. Danshen-Honghua Ameliorates Stress-Induced Menopausal Depression in Rats. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1210284
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210284
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر