Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy
المؤلفون المشاركون
Delmotte, Jean-Baptiste
Tutakhail, Abdulkarim
Abdallah, Kahina
Reach, Pauline
D’Ussel, Marguerite
Deplanque, Gael
Beaussier, Hélène
Coudoré, François
المصدر
Neurology Research International
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
Oxaliplatin is a platinum compound widely used in gastrointestinal cancer treatment but produces dose-limiting peripheral neuropathy.
New insights into oxaliplatin-induced peripheral neuropathy (OIPN) assessment are needed to detect more effectively this condition.
In this context, we conducted Canaloxa study, a prospective preliminary clinical trial that aimed to investigate how Electrochemical Skin Conductance (ESC), a parameter used in small fiber neuropathy assessment, could be helpful in OIPN diagnosis.
Methods.
Cancer patients treated for at least three months with oxaliplatin and suffering from clinically OIPN were included.
Electrochemical Skin Conductance, thermal thresholds, and neuropathic pain were assessed in all included patients.
Results.
During one year, 36 patients were included.
The main result was the correlation between ESC and Neuropathic Pain Symptom Inventory score for hands (rho value = -0.69, p < 0.0001) and feet (rho value = -0.79, p < 0.0001).
ESC values were lower in neuropathic patients with painful symptoms than in ones without painful symptoms (p = 0.0003 and p < 0.0001 for hands and feet, respectively).
No correlation was observed between ESC and thermal thresholds.
Conclusion.
These preliminary data suggest that ESC could be a useful objective marker of painful oxaliplatin-induced neuropathy and could complement the use of subjective clinical scales.
This study was prospectively registered on clinicaltrials.gov ( NCT02827916 ) before patient recruitment has begun.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Delmotte, Jean-Baptiste& Tutakhail, Abdulkarim& Abdallah, Kahina& Reach, Pauline& D’Ussel, Marguerite& Deplanque, Gael…[et al.]. 2018. Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy. Neurology Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210576
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Delmotte, Jean-Baptiste…[et al.]. Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy. Neurology Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1210576
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Delmotte, Jean-Baptiste& Tutakhail, Abdulkarim& Abdallah, Kahina& Reach, Pauline& D’Ussel, Marguerite& Deplanque, Gael…[et al.]. Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy. Neurology Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210576
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210576
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر