Serotonin Reuptake Inhibitors in Obstructive Sleep Apnea: Associations in People with and without Epilepsy
المؤلف
المصدر
Neurology Research International
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
Positive airway pressure remains the gold-standard treatment for OSA, but many are intolerant.
The neurotransmitter serotonin is involved in respiratory control.
Evidence exists for SRIs in reducing OSA severity in the general population and ictal hypoxemia and seizure-induced respiratory arrest in people with epilepsy (PWE).
However, the association between SRIs and OSA severity has not been studied in populations consisting of both groups.
This study aims to determine if SRIs are associated with OSA severity in both PWE and people without epilepsy (PWO) and whether differences exist between the two groups.
Methods.
A retrospective study of adults with OSA was conducted.
Subjects were categorized as PWE or PWO and for the use (+SRI) or absence (-SRI) of an SRI.
The primary outcome was OSA severity relative to SRI status.
OSA severity as a function of SRI status was also compared between PWE and PWO and within the PWE and PWO cohorts.
Oxygen saturation nadir was a secondary outcome measure.
Statistical adjustment of pertinent characteristics was performed.
Results.
There were 125 subjects (57 PWE, 68 PWO, 80 –SRI, and 45 +SRI).
+SRI was associated with reduced odds of severe compared to moderate OSA, in unadjusted and adjusted analysis.
Compared to PWO, PWE demonstrated a more robust association between OSA severity and +SRI.
When analyzed as separate cohorts, only PWE demonstrated reduced OSA severity, with adjustment for age (OR:0.140, CI:0.021-1.116, and p=0.042).
Oxygen saturation nadir was not significant in any model.
Conclusions.
SRIs represent a potential treatment option for OSA and may demonstrate a more robust association with reduced OSA severity in PWE compared to PWO.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheng, Jocelyn Y.. 2018. Serotonin Reuptake Inhibitors in Obstructive Sleep Apnea: Associations in People with and without Epilepsy. Neurology Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210612
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheng, Jocelyn Y.. Serotonin Reuptake Inhibitors in Obstructive Sleep Apnea: Associations in People with and without Epilepsy. Neurology Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1210612
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheng, Jocelyn Y.. Serotonin Reuptake Inhibitors in Obstructive Sleep Apnea: Associations in People with and without Epilepsy. Neurology Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1210612
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210612
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر